12 岁男孩在完成肝母细胞瘤治疗 17 个月后患恶性黑色素瘤。
Malignant melanoma in a 12-year-old boy 17 months after completing hepatoblastoma treatment.
机构信息
Pediatrics, Nihon University Itabashi Hospital, Tokyo, Japan.
Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
出版信息
Cancer Rep (Hoboken). 2024 May;7(5):e2118. doi: 10.1002/cnr2.2118.
BACKGROUND
Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.
CASE
We report a case of a 12-year-old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6 weeks after being diagnosed with melanoma. Whole-exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ-line variants.
CONCLUSION
This case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.
背景
黑色素瘤作为儿童癌症幸存者的继发性恶性肿瘤较为罕见。
病例报告
我们报告了一例 12 岁男孩的病例，他在完成肝母细胞瘤治疗 17 个月后发生了伴全身转移的恶性黑色素瘤。诊断出乎意料，是基于骨髓检查做出的。患者对免疫检查点抑制剂治疗无反应，在诊断为黑色素瘤后 6 周死亡。对与癌症易感性相关的 103 个基因进行全外显子测序，未发现任何种系变异。
结论
本病例研究提供了儿童癌症幸存者在接受肝母细胞瘤治疗后发生黑色素瘤的一个独特范例，但未发现任何候选变异与肝母细胞瘤和黑色素瘤相关。
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