Zavadzki Giovanna, Inzunza Robles José, San Martín María Fernanda, Gutiérrez Torres Waldo, Ramos-Rojas José Tomás, Gauna-Cordero Jamil, Bigossi Aguiar Natalia
Hospital Dr Sótero del Río, Fundación Epistemonikos, Universidad Federal de Sao Paulo, Brasil.
Universidad Católica de Chile, Santiago, Chile.
Rev Med Chil. 2023 Jun;151(6):797-800. doi: 10.4067/s0034-98872023000600797.
Human intoxication by long-acting anticoagulant rodenticides, known as superwarfarins, causes coagulopathy that is difficult to manage. We present the case of a 42-year-old man who ingested a toxic dose of rodenticide in a suicide attempt, evolving with epistaxis, INR of 11.6, and needing hospitalization. For seven days, serial controls of coagulation tests were carried out, with optimization of different doses of Vitamin K supplementation. The case highlights this type of anticoagulant's potency and prolonged half-life (approximately six weeks), which requires regular clinical control and satisfactory treatment adherence.
人类因长效抗凝血灭鼠剂（即所谓的超级华法林）中毒会引发难以处理的凝血病。我们报告一例42岁男性病例，该患者为自杀而摄入了有毒剂量的灭鼠剂，出现鼻出血、国际标准化比值（INR）为11.6的症状，需要住院治疗。连续七天进行凝血试验的系列检查，并优化不同剂量的维生素K补充治疗。该病例凸显了这类抗凝剂的强效性和较长的半衰期（约六周），这需要定期进行临床检查并确保患者对治疗的依从性良好。
