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[处理超级华法林中毒:一个具有挑战性的病例]

[Managing Superwarfarin Poisoning: A Challenging Case].

作者信息

Zavadzki Giovanna, Inzunza Robles José, San Martín María Fernanda, Gutiérrez Torres Waldo, Ramos-Rojas José Tomás, Gauna-Cordero Jamil, Bigossi Aguiar Natalia

机构信息

Hospital Dr Sótero del Río, Fundación Epistemonikos, Universidad Federal de Sao Paulo, Brasil.

Universidad Católica de Chile, Santiago, Chile.

出版信息

Rev Med Chil. 2023 Jun;151(6):797-800. doi: 10.4067/s0034-98872023000600797.

Abstract

Human intoxication by long-acting anticoagulant rodenticides, known as superwarfarins, causes coagulopathy that is difficult to manage. We present the case of a 42-year-old man who ingested a toxic dose of rodenticide in a suicide attempt, evolving with epistaxis, INR of 11.6, and needing hospitalization. For seven days, serial controls of coagulation tests were carried out, with optimization of different doses of Vitamin K supplementation. The case highlights this type of anticoagulant's potency and prolonged half-life (approximately six weeks), which requires regular clinical control and satisfactory treatment adherence.

摘要

人类因长效抗凝血灭鼠剂(即所谓的超级华法林)中毒会引发难以处理的凝血病。我们报告一例42岁男性病例,该患者为自杀而摄入了有毒剂量的灭鼠剂,出现鼻出血、国际标准化比值(INR)为11.6的症状,需要住院治疗。连续七天进行凝血试验的系列检查,并优化不同剂量的维生素K补充治疗。该病例凸显了这类抗凝剂的强效性和较长的半衰期(约六周),这需要定期进行临床检查并确保患者对治疗的依从性良好。

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