Department of Pharmacy, Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.
Pediatr Nephrol. 2024 Dec;39(12):3397-3410. doi: 10.1007/s00467-024-06414-5. Epub 2024 May 27.
Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involved in the inflammation and fibrosis observed in kidney injury. MicroRNA (miRNA), a type of short RNA lacking protein-coding function, can inhibit specific mRNA by partially binding to its target mRNA. The intricate association between miRNAs and macrophages has been attracting increasing interest in recent years. This review discusses the role of miRNAs in regulating macrophage-mediated kidney injury. It shows how miRNAs can influence macrophage polarization, thereby altering the biological function of macrophages in the kidney. Furthermore, this review highlights the significance of miRNAs derived from exosomes and extracellular vesicles as a crucial mediator in the crosstalk between macrophages and kidney cells. The potential of miRNAs as treatment applications and biomarkers for macrophage-mediated kidney injury is also discussed.
巨噬细胞是人体免疫系统的重要组成部分，可极化为 M1/M2 表型，每种表型具有不同的功能和作用。巨噬细胞极化被报道与肾脏损伤中观察到的炎症和纤维化有显著关系。微小 RNA（miRNA）是一种缺乏蛋白编码功能的短 RNA，可通过部分结合其靶 mRNA 来抑制特定的 mRNA。miRNA 与巨噬细胞之间的复杂关系近年来引起了越来越多的关注。本文讨论了 miRNA 在调节巨噬细胞介导的肾脏损伤中的作用。它表明 miRNA 如何影响巨噬细胞极化，从而改变巨噬细胞在肾脏中的生物学功能。此外，本文还强调了外泌体和细胞外囊泡衍生的 miRNA 作为巨噬细胞和肾脏细胞之间串扰的关键介质的重要性。还讨论了 miRNA 作为治疗应用和巨噬细胞介导的肾脏损伤生物标志物的潜力。
