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CAR T cells put the brakes on asthma.

作者信息

Lambrecht Bart N, Hammad Hamida

机构信息

Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

出版信息

Nat Immunol. 2024 Jun;25(6):935-937. doi: 10.1038/s41590-024-01851-8.

DOI:10.1038/s41590-024-01851-8

PMID:38802513

Abstract

摘要

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J Exp Med. 2024 May 6;221(5). doi: 10.1084/jem.20232368. Epub 2024 Mar 26.

The Pathology of Asthma: What Is Obstructing Our View?

Annu Rev Pathol. 2023 Jan 24;18:387-409. doi: 10.1146/annurev-pathol-042220-015902. Epub 2022 Oct 21.

Biologic Therapies for Severe Asthma.

N Engl J Med. 2022 Jan 13;386(2):157-171. doi: 10.1056/NEJMra2032506.

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Cell. 2021 Apr 29;184(9):2521-2522. doi: 10.1016/j.cell.2021.04.019.

Cellular networks controlling T cell persistence in adoptive cell therapy.

Nat Rev Immunol. 2021 Dec;21(12):769-784. doi: 10.1038/s41577-021-00539-6. Epub 2021 Apr 20.

The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma.

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The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.

J Exp Med. 2020 Dec 7;217(12). doi: 10.1084/jem.20190706.

Human airway epithelial cells express a functional IL-5 receptor.

Allergy. 2020 Aug;75(8):2127-2130. doi: 10.1111/all.14297. Epub 2020 Apr 14.

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相似文献

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Nat Immunol. 2024 Jun;25(6):935-937. doi: 10.1038/s41590-024-01851-8.

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Mol Ther. 2020 Oct 7;28(10):2108-2110. doi: 10.1016/j.ymthe.2020.08.011. Epub 2020 Aug 25.

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Mol Ther. 2024 Oct 2;32(10):3204-3206. doi: 10.1016/j.ymthe.2024.08.025. Epub 2024 Sep 11.

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Blood Cancer Discov. 2024 Jul 1;5(4):229-233. doi: 10.1158/2643-3230.BCD-23-0273.

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引用本文的文献

Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.

Clin Rev Allergy Immunol. 2025 Feb 11;68(1):13. doi: 10.1007/s12016-024-09020-3.

本文引用的文献

A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice.

Nat Immunol. 2024 Jun;25(6):1059-1072. doi: 10.1038/s41590-024-01834-9. Epub 2024 May 27.

Induction of immortal-like and functional CAR T cells by defined factors.

J Exp Med. 2024 May 6;221(5). doi: 10.1084/jem.20232368. Epub 2024 Mar 26.

The Pathology of Asthma: What Is Obstructing Our View?

Annu Rev Pathol. 2023 Jan 24;18:387-409. doi: 10.1146/annurev-pathol-042220-015902. Epub 2022 Oct 21.

Biologic Therapies for Severe Asthma.

N Engl J Med. 2022 Jan 13;386(2):157-171. doi: 10.1056/NEJMra2032506.

The basic immunology of asthma.

Cell. 2021 Apr 29;184(9):2521-2522. doi: 10.1016/j.cell.2021.04.019.

Cellular networks controlling T cell persistence in adoptive cell therapy.

Nat Rev Immunol. 2021 Dec;21(12):769-784. doi: 10.1038/s41577-021-00539-6. Epub 2021 Apr 20.

The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma.

BMC Cancer. 2021 Jan 19;21(1):82. doi: 10.1186/s12885-021-07806-8.

The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.

J Exp Med. 2020 Dec 7;217(12). doi: 10.1084/jem.20190706.

Human airway epithelial cells express a functional IL-5 receptor.

Allergy. 2020 Aug;75(8):2127-2130. doi: 10.1111/all.14297. Epub 2020 Apr 14.

A bispecific antibody strategy to target multiple type 2 cytokines in asthma.

J Allergy Clin Immunol. 2018 Oct;142(4):1185-1193.e4. doi: 10.1016/j.jaci.2018.06.002. Epub 2018 Jun 8.