Department of Pediatrics and Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Department of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
Allergy. 2020 Aug;75(8):2127-2130. doi: 10.1111/all.14297. Epub 2020 Apr 14.
We found that HBEC expressed the IL-5 receptor, which triggered intracellular signaling and changed gene expression. This data indicate that in addition to targeting eosinophils, IL-5 and anti-IL-5 biologics may have a direct role on AEC.
我们发现 HBEC 表达了 IL-5 受体,该受体触发了细胞内信号转导并改变了基因表达。这些数据表明,除了靶向嗜酸性粒细胞外,IL-5 和抗 IL-5 生物制剂可能对 AEC 具有直接作用。