Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Endocrinol (Lausanne). 2024 May 13;15:1383483. doi: 10.3389/fendo.2024.1383483. eCollection 2024.
1,5-Anhydroglucitol (1,5-AG) is sensitive to short-term glucose fluctuations and postprandial hyperglycemia, which has great potential in the clinical application of diabetes as a nontraditional blood glucose monitoring indicator. A large number of studies have found that 1,5-AG can be used to screen for diabetes, manage diabetes, and predict the perils of diabetes complications (diabetic nephropathy, diabetic cardiovascular disease, diabetic retinopathy, diabetic pregnancy complications, diabetic peripheral neuropathy, etc.). Additionally, 1,5-AG and β cells are also associated with each other. As a noninvasive blood glucose monitoring indicator, salivary 1,5-AG has much more benefit for clinical application; however, it cannot be ignored that its detection methods are not perfect. Thus, a considerable stack of research is still needed to establish an accurate and simple enzyme assay for the detection of salivary 1,5-AG. More clinical studies will also be required in the future to confirm the normal reference range of 1,5-AG and its role in diabetes complications to further enhance the blood glucose monitoring system for diabetes.
1,5-脱水山梨醇（1,5-AG）对短期血糖波动和餐后高血糖敏感，在糖尿病的临床应用中作为一种非传统的血糖监测指标具有很大的潜力。大量研究发现，1,5-AG 可用于糖尿病筛查、糖尿病管理和预测糖尿病并发症的危险（糖尿病肾病、糖尿病心血管疾病、糖尿病视网膜病变、糖尿病妊娠并发症、糖尿病周围神经病变等）。此外，1,5-AG 与β细胞也有关联。作为一种非侵入性的血糖监测指标，唾液 1,5-AG 更有利于临床应用；然而，不能忽视的是其检测方法并不完善。因此，仍需要相当多的研究来建立一种准确而简单的酶分析法来检测唾液 1,5-AG。未来还需要更多的临床研究来确定 1,5-AG 的正常参考范围及其在糖尿病并发症中的作用，以进一步增强糖尿病的血糖监测系统。
