Arrué Patricio, Laksari Kaveh, Russo Mark, La Placa Tana, Smith Meghan, Toosizadeh Nima
Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.
Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ, United States.
Front Aging. 2024 May 13;5:1396636. doi: 10.3389/fragi.2024.1396636. eCollection 2024.
Frailty is a geriatric syndrome associated with the lack of physiological reserve and consequent adverse outcomes (therapy complications and death) in older adults. Recent research has shown associations between heart rate (HR) dynamics (HR changes during physical activity) with frailty. The goal of the present study was to determine the effect of frailty on the interconnection between motor and cardiac systems during a localized upper-extremity function (UEF) test. Fifty-six individuals aged 65 or above were recruited and performed the previously developed UEF test consisting of 20-s rapid elbow flexion with the right arm. Frailty was assessed using the Fried phenotype. Wearable gyroscopes and electrocardiography were used to measure motor function and HR dynamics. In this study, the interconnection between motor (angular displacement) and cardiac (HR) performance was assessed, using convergent cross-mapping (CCM). A significantly weaker interconnection was observed among pre-frail and frail participants compared to non-frail individuals ( < 0.01, effect size = 0.81 ± 0.08). Using logistic models, pre-frailty and frailty were identified with sensitivity and specificity of 82%-89%, using motor, HR dynamics, and interconnection parameters. Findings suggested a strong association between cardiac-motor interconnection and frailty. Adding CCM parameters in a multimodal model may provide a promising measure of frailty.
衰弱是一种老年综合征，与老年人缺乏生理储备以及随之而来的不良后果（治疗并发症和死亡）相关。最近的研究表明心率（HR）动态变化（身体活动期间的心率变化）与衰弱之间存在关联。本研究的目的是确定在局部上肢功能（UEF）测试期间衰弱对运动系统和心脏系统之间相互联系的影响。招募了56名65岁及以上的个体，让他们进行先前开发的UEF测试，该测试包括用右臂进行20秒的快速肘部屈曲。使用Fried表型评估衰弱情况。使用可穿戴陀螺仪和心电图来测量运动功能和心率动态变化。在本研究中，使用收敛交叉映射（CCM）评估运动（角位移）和心脏（心率）表现之间的相互联系。与非衰弱个体相比，在衰弱前期和衰弱参与者中观察到明显较弱的相互联系（<0.01，效应大小=0.81±0.08）。使用逻辑模型，利用运动、心率动态变化和相互联系参数，以82%-89%的敏感性和特异性识别衰弱前期和衰弱情况。研究结果表明心脏-运动相互联系与衰弱之间存在密切关联。在多模态模型中添加CCM参数可能为衰弱提供一种有前景的测量方法。
