Ruvalcaba-Delgadillo Yaveth, Martínez-Fernández Diana Emilia, Luquin Sonia, Moreno-Alcázar Ana, Redolar-Ripoll Diego, Jauregui-Huerta Fernando, Fernández-Quezada David
Neuroscience Department, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Transdisciplinary Institute of Research and Services (ITRANS), University of Guadalajara, Zapopan, Mexico.
Front Psychiatry. 2024 May 13;15:1396550. doi: 10.3389/fpsyt.2024.1396550. eCollection 2024.
Stress is a pervasive health concern known to induce physiological changes, particularly impacting the vulnerable hippocampus and the morphological integrity of its main residing cells, the hippocampal neurons. Eye Movement Desensitization and Reprocessing (EMDR), initially developed to alleviate emotional distress, has emerged as a potential therapeutic/preventive intervention for other stress-related disorders. This study aimed to investigate the impact of Acute Variable Stress (AVS) on hippocampal neurons and the potential protective effects of EMDR.
Rats were exposed to diverse stressors for 7 days, followed by dendritic morphology assessment of hippocampal neurons using Golgi-Cox staining.
AVS resulted in significant dendritic atrophy, evidenced by reduced dendritic branches and length. In contrast, rats receiving EMDR treatment alongside stress exposure exhibited preserved dendritic morphology comparable to controls, suggesting EMDR's protective role against stressinduced dendritic remodeling.
These findings highlight the potential of EMDR as a neuroprotective intervention in mitigating stress-related hippocampal alterations.
压力是一个普遍存在的健康问题，已知会引起生理变化，尤其会影响脆弱的海马体及其主要驻留细胞——海马神经元的形态完整性。眼动脱敏再处理疗法（EMDR）最初是为缓解情绪困扰而开发的，现已成为针对其他与压力相关疾病的一种潜在治疗/预防干预措施。本研究旨在调查急性可变应激（AVS）对海马神经元的影响以及EMDR的潜在保护作用。
将大鼠暴露于多种应激源7天，然后使用高尔基-考克斯染色法评估海马神经元的树突形态。
AVS导致显著的树突萎缩，表现为树突分支和长度减少。相比之下，在接受应激暴露的同时接受EMDR治疗的大鼠表现出与对照组相当的树突形态，这表明EMDR对压力诱导的树突重塑具有保护作用。
这些发现凸显了EMDR作为一种神经保护干预措施在减轻与压力相关的海马体改变方面的潜力。
