Nakhla Nardine R, Houle Sherilyn K D, Taylor Jeffrey G
School of Pharmacy, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Pharmacy (Basel). 2024 May 22;12(3):81. doi: 10.3390/pharmacy12030081.
The shift of proton pump inhibitors (PPIs) from prescription to nonprescription (nonRx) status in Canada has altered pharmacist treatment options for heartburn. This report examines pharmacist approaches to therapy based on case severity; pharmacist confidence and consult duration were also explored. A 2022 online survey gathered data from Ontario and Québec pharmacists regarding their therapeutic approaches for two hypothetical heartburn cases. A total of 715 pharmacists participated, with most having 1-10 years of experience. In Ontario, common choices for the milder case included a solo histamine-2 receptor antagonist (H2RA) (21.2%), combination H2RA + antacid (29.4%), and nonRx PPI (22.3%). For the more severe case, common choices for Québec were switches to nonRx H2RA (22.1%), combination H2RA + antacid (13.4%), a nonRx PPI (24.9%), or prescription PPI (22.5%). Pharmacists often recommended switching medications or referring patients with recurring symptoms after seven days. The approaches varied significantly between cases and provinces. The Ontario pharmacists favoured a combination H2RA + antacid for the milder case, while the Québec pharmacists preferred a solo H2RA. For the more severe case, both groups often chose nonRx H2RA followed by nonRx PPI. Despite the differences, the pharmacists demonstrated confidence in managing these situations. These findings highlight potential debates regarding optimal therapeutic approaches and the impact of drug scheduling on patient care.
质子泵抑制剂(PPIs)在加拿大从处方药转为非处方药状态,改变了药剂师治疗胃灼热的选择。本报告根据病例严重程度研究了药剂师的治疗方法;还探讨了药剂师的信心和咨询时长。一项2022年的在线调查收集了安大略省和魁北克省药剂师关于两个假设胃灼热病例治疗方法的数据。共有715名药剂师参与,大多数有1至10年工作经验。在安大略省,较轻病例的常见选择包括单独使用组胺-2受体拮抗剂(H2RA)(21.2%)、H2RA与抗酸剂联合使用(29.4%)以及非处方PPI(22.3%)。对于较严重病例,魁北克省的常见选择是改用非处方H2RA(22.1%)、H2RA与抗酸剂联合使用(13.4%)、非处方PPI(24.9%)或处方PPI(22.5%)。药剂师通常建议在七天后更换药物或转诊有反复症状的患者。不同病例和省份的治疗方法差异很大。安大略省的药剂师在较轻病例中更倾向于H2RA与抗酸剂联合使用,而魁北克省的药剂师则更喜欢单独使用H2RA。对于较严重病例,两组通常先选择非处方H2RA,然后是非处方PPI。尽管存在差异,但药剂师在处理这些情况时表现出信心。这些发现凸显了关于最佳治疗方法以及药物分类对患者护理影响的潜在争议。