School of Future Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
Fuzhou Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China.
ChemMedChem. 2024 Sep 2;19(17):e202400223. doi: 10.1002/cmdc.202400223. Epub 2024 Jul 15.
The abnormal aggregation of Aβ has been considered one of the primary causative factors for Alzheimer's disease. Diverse molecular entities have been developed to mitigate the formation of toxic Aβ aggregates within the brain by inhibiting Aβ aggregation. Recognizing that many FDA-approved drugs are derived from natural products, we present a summary of recent discoveries involving natural product molecules with inhibitory effects on Aβ aggregation. By consolidating these findings, our review offers researchers a concise overview of the latest advancements in natural product-based interventions for Alzheimer's disease.
异常聚集的 Aβ 已被认为是阿尔茨海默病的主要致病因素之一。已经开发出多种分子实体来通过抑制 Aβ 聚集来减轻大脑中有毒 Aβ 聚集物的形成。鉴于许多 FDA 批准的药物源自天然产物，我们总结了具有抑制 Aβ 聚集作用的天然产物分子的最新发现。通过整合这些发现，我们的综述为研究人员提供了一个关于基于天然产物干预阿尔茨海默病的最新进展的简明概述。
