硒对自身免疫性甲状腺功能减退症患者抗甲状腺球蛋白抗体的影响：一项随机对照试验。
Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.
作者信息
AkbariRad Mina, Mazloum Khorasani Zahra, Beizae Behnam, Ayatollahi Hossein, Emadzadeh Maryam, Sarabi Mehrdad, Saeedi Nikoo, Nekooei Negar
机构信息
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Caspian J Intern Med. 2024 Spring;15(2):340-346. doi: 10.22088/cjim.15.2.340.
BACKGROUND
The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.
METHODS
In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; one group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.
RESULTS
After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.
CONCLUSION
Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.
背景
本研究旨在评估口服硒对自身免疫性甲状腺功能减退患者抗Tg抗体的影响。
方法
在这项双盲随机对照试验中，将两组各72名自身免疫性甲状腺功能减退患者随机分组；一组接受左甲状腺素（LT4）和口服硒，另一组接受LT4加安慰剂。在治疗前及治疗3个月后对两组患者的抗Tg抗体、游离T4、抗TPO抗体和促甲状腺激素进行检测，并使用SPSS软件进行数据分析。
结果
干预后，两组患者的抗Tg抗体平均量均下降，且干预组的下降更为明显（P = 0.03）。干预组干预后促甲状腺激素水平下降（p < 0.05），游离T4水平升高（p < 0.05）；这两个变量的变化具有统计学意义。
结论
与安慰剂相比，自身免疫性甲状腺功能减退患者服用硒可显著降低抗Tg抗体水平，并显著提高游离T4水平。此外，与对照组相比，促甲状腺激素水平下降幅度更大。
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