Besharat Sima, Sakhavi Farideh, Sookhtehsaraei Parsa, Teimoorian Mehrdad, Livani Somayeh, Norouzi Alireza, Amiriani Taghi
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Golestan, Gorgan, Iran.
Caspian J Intern Med. 2024 Spring;15(2):299-306. doi: 10.22088/cjim.15.2.299.
According to the significance of extraintestinal symptoms in inflammatory bowel disease (IBD) patients and their connection with obesity, we aimed to investigate the prevalence of fatty liver in IBD patients of Sayyad Shirazi Hospital in Gorgan, Iran, in relation to obesity, anthropometric indicators and body image in these patients.
Forty patients with IBD were recruited from all registered patients at the Golestan Research Center of Gastroenterology and Hepatology, following the specified inclusion and exclusion criteria. After obtaining written informed consent and filling in the questionnaire, the demographic and anthropometric indicators, and variables related to the disease were measured. The liver sonography was performed on all patients and graded by an expert radiologist. Data were analyzed using SPSS Version 16.0 statistical software at the significance level of 0.05.
We showed no significant difference between the distribution of demographic and anthropometric indicators in different groups of IBD patients. However, we demonstrated that the inappropriate values of HDL (0.004) and high values of LDL (0.015) were associated with fatty liver in IBD patients. Our findings also showed that NAFLD was significantly associated with overweight and obesity among IBD patients (P = 0.003).
Our findings showed the epidemiological burden of NAFLD in IBD patients. Since fatty liver was associated with obesity, it is recommended that IBD patients be screened for risk factors associated with NAFLD to prevent liver disease.
根据炎症性肠病（IBD）患者肠外症状的重要性及其与肥胖的关联，我们旨在调查伊朗戈尔甘赛义德·希拉齐医院IBD患者中脂肪肝的患病率，以及这些患者的肥胖情况、人体测量指标和身体形象。
按照指定的纳入和排除标准，从戈勒斯坦胃肠病学和肝病研究中心的所有登记患者中招募了40例IBD患者。在获得书面知情同意并填写问卷后，测量了人口统计学和人体测量指标以及与疾病相关的变量。对所有患者进行肝脏超声检查，并由一名放射科专家进行分级。使用SPSS 16.0统计软件在显著性水平为0.05的情况下对数据进行分析。
我们发现不同组IBD患者的人口统计学和人体测量指标分布之间没有显著差异。然而，我们证明IBD患者中高密度脂蛋白（HDL）的不适当值（0.004）和低密度脂蛋白（LDL）的高值（0.015）与脂肪肝有关。我们的研究结果还表明，非酒精性脂肪性肝病（NAFLD）与IBD患者中的超重和肥胖显著相关（P = 0.003）。
我们的研究结果显示了IBD患者中非酒精性脂肪性肝病的流行病学负担。由于脂肪肝与肥胖有关，建议对IBD患者进行与非酒精性脂肪性肝病相关的危险因素筛查，以预防肝脏疾病。
