氯氮平对致神经源性锥体外系运动障碍的影响（作者译）
[Influence of clozapine on neuroleptigenic extrapyramidal motor disturbances (author's transl)].
作者信息
Zander K J, Rüther E
出版信息
Arzneimittelforschung. 1978;28(9):1495-6.
PMID:38808
Abstract
- Human neuroleptogenic EPMS-disturbances are reversed by clozapine in animal experiments and in clinical use. This is consistent with the central anticholinergic efficacy of clozapine. 2. Clozapine seems to be a favourable concomitant medication when high dosage therapy of neuroleptics is applied--or at the incidence of dyskinesia.
摘要
- 在动物实验和临床应用中，氯氮平可逆转人类由抗精神病药物引起的迟发性运动障碍（EPMS）紊乱。这与氯氮平的中枢抗胆碱能功效相符。2. 当应用高剂量抗精神病药物治疗时——或在出现运动障碍的情况下，氯氮平似乎是一种有益的辅助药物。
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