Lei Jiang, He Wenxuan, Liu Yao, Zhang Qinxin, Liu Yingyao, Ou Qican, Wu Xianli, Li Fenglin, Liao Jiajia, Xiao Yousheng
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Neurology, The First People's Hospital of Nanning, Nanning, China.
Front Aging Neurosci. 2024 May 14;16:1377719. doi: 10.3389/fnagi.2024.1377719. eCollection 2024.
The association between hypothyroidism and Parkinson's disease (PD) has sparked intense debate in the medical community due to conflicting study results. A better understanding of this association is crucial because of its potential implications for both pathogenesis and treatment strategies.
To elucidate this complex relationship, we used Bayesian co-localisation (COLOC) and bidirectional Mendelian randomization (MR) analysis. COLOC was first used to determine whether hypothyroidism and PD share a common genetic basis. Subsequently, genetic variants served as instrumental variables in a bidirectional MR to explore causal interactions between these conditions.
COLOC analysis revealed no shared genetic variants between hypothyroidism and PD, with probability of hypothesis 4 (PPH4) = 0.025. Furthermore, MR analysis indicated that hypothyroidism does not have a substantial causal effect on PD (OR = 0.990, 95% CI = 0.925, 1.060, = 0.774). Conversely, PD appears to have a negative causal effect on hypothyroidism (OR = 0.776, 95% CI = 0.649, 0.928, = 0.005).
Our findings suggest the absence of shared genetic variants between hypothyroidism and PD. Interestingly, PD may inversely influence the risk of developing hypothyroidism, a finding that may inform future research and clinical approaches.
由于研究结果相互矛盾，甲状腺功能减退与帕金森病（PD）之间的关联在医学界引发了激烈的争论。由于其对发病机制和治疗策略的潜在影响，更好地理解这种关联至关重要。
为了阐明这种复杂的关系，我们使用了贝叶斯共定位（COLOC）和双向孟德尔随机化（MR）分析。首先使用COLOC来确定甲状腺功能减退和PD是否共享一个共同的遗传基础。随后，基因变异在双向MR中作为工具变量，以探索这些疾病之间的因果相互作用。
COLOC分析显示甲状腺功能减退和PD之间没有共享的基因变异，假设4的概率（PPH4）=0.025。此外，MR分析表明甲状腺功能减退对PD没有实质性的因果效应（OR=0.990，95%CI=0.925，1.060，P=0.774）。相反，PD似乎对甲状腺功能减退有负面的因果效应（OR=0.776，95%CI=0.649，0.928，P=0.005）。
我们的研究结果表明甲状腺功能减退和PD之间不存在共享的基因变异。有趣的是，PD可能会反向影响患甲状腺功能减退的风险，这一发现可能为未来的研究和临床方法提供参考。
