Dong Yufan, Guo Yuhong, Li Qin, Zhao Yihe, Cao Jianxin
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, China.
Institute of Forestry Industry, Yunnan, Academy of forestry and grassland, Kunming, China.
Food Chem X. 2024 May 16;22:101472. doi: 10.1016/j.fochx.2024.101472. eCollection 2024 Jun 30.
Bamboo shoot has long been regarded as a nutritious and healthy food. It is low in calorie and rich in high-quality dietary fiber (DF), making them a potential DF resource. However, the protective mechanism of soluble dietary fibers from (Munro) Kurz shoot (DS-SDF) on methionine and choline deficient (MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) is still unclear. This study was aimed to investigate the regulation of DS-SDF on gut microbiota in MCD diet-induced mice and its potential protective effect on liver injury. The NAFLD model was induced by the MCD diet for 8 weeks. Through observation of changes in liver function and gut microorganisms, it was found that DS-SDF supplementation could inhibit liver inflammation, improve liver injury, regulate the diversity of gut microorganisms, increase the abundance of beneficial bacteria and short-chain fatty acid-producing bacteria, and reverse the gut disorders induced by the MCD diet in mice. This study showed that DS-SDF supplementation could treat NAFLD by regulating gut microbiota composition, improving liver function, and inhibiting the inflammatory response. It might broaden the idea of high-value utilization of DS-SDF.
竹笋长期以来一直被视为一种营养健康的食物。它热量低，富含优质膳食纤维（DF），使其成为一种潜在的膳食纤维资源。然而，毛竹（Munro）库尔兹笋（DS-SDF）中可溶性膳食纤维对蛋氨酸和胆碱缺乏（MCD）饮食诱导的非酒精性脂肪性肝病（NAFLD）的保护机制仍不清楚。本研究旨在探讨DS-SDF对MCD饮食诱导小鼠肠道微生物群的调节作用及其对肝损伤的潜在保护作用。通过MCD饮食诱导8周建立NAFLD模型。通过观察肝功能和肠道微生物的变化，发现补充DS-SDF可以抑制肝脏炎症，改善肝损伤，调节肠道微生物的多样性，增加有益菌和产短链脂肪酸菌的丰度，并逆转MCD饮食诱导的小鼠肠道紊乱。本研究表明，补充DS-SDF可以通过调节肠道微生物群组成、改善肝功能和抑制炎症反应来治疗NAFLD。这可能拓宽DS-SDF高值利用的思路。
