Ghashghaee Mojtaba, Kaboudin Babak, Kazemi Foad, Hassan Maryam, Fukaya Haruhiko, Yanai Hikaru
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45137-66731, Iran.
Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.
J Org Chem. 2024 Jun 7;89(11):7662-7670. doi: 10.1021/acs.joc.4c00340. Epub 2024 May 29.
Organophosphorylated coumarin derivatives were synthesized by a three-component reaction of 4-chloro-3-formylcoumarin, aromatic amines, and dialkyl phosphite in the presence of ZnCl. This process includes the formation of C(sp)-P and C(sp)-N bonds in one pot. The modular scope of the reaction allowed rapid access to a variety of 6-chromeno[4,3-]quinolin-7-ylphosphonate derivatives in good yields. Furthermore, photophysical studies of the products revealed their stimulating fluorescence properties.
通过4-氯-3-甲酰基香豆素、芳香胺和亚磷酸二烷基酯在ZnCl存在下的三组分反应合成了有机磷酰化香豆素衍生物。该过程包括在一锅法中形成C(sp)-P键和C(sp)-N键。反应的模块化范围使得能够以良好的产率快速获得各种6-色烯并[4,3-]喹啉-7-基膦酸酯衍生物。此外，对产物的光物理研究揭示了它们具有激发荧光特性。
