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[鉴别致僵物质的作用(作者译)]

[Differentiating the action of cataleptogenic bodies (author's transl)].

作者信息

Menge H G, Brand U

出版信息

Arzneimittelforschung. 1978;28(9):1506-7.

PMID:38810
Abstract

Responses to several drugs called cataleptogenic as shown in the "Catalepsy Testbattery", were analyzed for their trigger mechanism. The results lead to the conclusion that the neurophysiological mechanisms of neuroleptic drugs are based on an inhibition of the processing of afferences. Therefore the term "experimental catalepsy" seems to be applicable only to these drugs. On the contrary, opioid drugs induce a state of rigidity which even can be increased by manipulating the animal. These conclusions are verified by electromyographical studies. In our opinion this syndrome should not be called "catalepsy" but "opiate stiffness".

摘要

针对在“僵住症测试组”中显示出的对几种称为致僵性药物的反应,分析了其触发机制。结果得出结论,抗精神病药物的神经生理机制基于对传入信息处理的抑制。因此,“实验性僵住症”这一术语似乎仅适用于这些药物。相反,阿片类药物会诱发一种僵硬状态,甚至通过对动物进行操作可使其加剧。这些结论通过肌电图研究得到了验证。我们认为,这种综合征不应称为“僵住症”,而应称为“阿片类药物僵硬”。

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