Hitchins A D, Wells P, McDonough F E, Wong N P
Am J Clin Nutr. 1985 Jan;41(1):92-100. doi: 10.1093/ajcn/41.1.92.
The response of yogurt-fed rats and the corresponding unfermented milk-fed rats to an infectious gastrointestinal challenge has been compared. After 1 (2 trials), 7 (4 trials), 14 and 21 (1 trial each) days on freeze-dried milk or yogurt diets, the rats were inoculated intra-gastrically by intubation per os with 4.5 X 10(10) +/- 0.7 colony forming units (mean +/- SEM) of Salmonella enteritidis. Challenged and control rats were monitored during the 3 weeks post-inoculation for viability, weight gain, feed consumption, and feed efficiency. In general, challenged yogurt-fed rats exhibited significantly superior weight gain and feed efficiency (but not feed consumption) values in week 1 post-infection, but the differences were not significant in week 2 post-infection. Sick milk- and yogurt-fed rats convalesced in week 3. Pooled mortality data indicated that yogurt-fed rats survived better than milk-fed rats. Yogurt did not prevent salmonellosis per se but significantly reduced the mortality and weight gain deceleration.
已对喂食酸奶的大鼠和相应喂食未发酵牛奶的大鼠对感染性胃肠道刺激的反应进行了比较。在以冻干牛奶或酸奶为食1天（2次试验）、7天（4次试验）、14天和21天（各1次试验）后，通过经口插管对大鼠进行胃内接种4.5×10¹⁰±0.7菌落形成单位（平均值±标准误）的肠炎沙门氏菌。在接种后的3周内，对受挑战的大鼠和对照大鼠进行监测，观察其活力、体重增加、饲料消耗和饲料效率。总体而言，受挑战的喂食酸奶的大鼠在感染后第1周表现出明显更高的体重增加和饲料效率（但饲料消耗无差异），但在感染后第2周差异不显著。生病的喂食牛奶和酸奶的大鼠在第3周康复。汇总的死亡率数据表明，喂食酸奶的大鼠比喂食牛奶的大鼠存活情况更好。酸奶本身并不能预防沙门氏菌病，但能显著降低死亡率和体重增加减速。
