Cytoplasmic inclusions in hepatocytes of bone marrow transplant patients: light and electron microscopic characterization.

Large eosinophilic, cytoplasmic inclusions were observed at autopsy in the hepatocytes of three patients who received bone marrow transplants for acute leukemia. The eosinophilic inclusions were not associated with any additional specific morphologic change in the liver. While similar inclusions have been observed in rats during hepatic regeneration following partial hepatectomy and in human hepatomas, to the authors' knowledge, such inclusions have not been described previously in patients who have received bone marrow grafts.