Kreiskott H, Hofmann H P
Arzneimittelforschung. 1978;28(9):1509-11.
Excitatory reactions elicited by pilocarpine HCl (50 mg/kg i.v. in 6 s) are used for demonstrating synergistic effects of the central anticholinergic drug biperiden (Akineton) and the antihistamine bamipine (Soventol). Scratching movements of the hind legs are used as parameter for central activity, salivation for peripheral and death for toxic drug effect, respectively. The results show distinct synergistic (central) activity of drug combinations concerning the inhibition of scratching movements. On the contrary, no intensified inhibition is found with the peripheal symptom salivation bamipine rather induces an attenuation of inhibitory effects seen after hig doses of biperiden. Furthermore, the enhanced toxicity of pilocarpine caused by bamipine in a defined dosage range is antagonized by biperiden in a dose related manner. The results of the animal experiments presented are paralleled with clinical experience.
盐酸毛果芸香碱（50毫克/千克静脉注射，6秒内注射完毕）引发的兴奋反应被用于证明中枢抗胆碱能药物安克痉（Akineton）和抗组胺药苄替米星（Soventol）的协同作用。后腿的搔抓动作分别用作中枢活性的参数，唾液分泌用作外周活性的参数，死亡用作药物毒性作用的参数。结果显示，药物组合在抑制搔抓动作方面具有明显的协同（中枢）活性。相反，未发现外周症状唾液分泌有增强的抑制作用，苄替米星反而会减弱高剂量安克痉后所见的抑制作用。此外，在特定剂量范围内，苄替米星引起的毛果芸香碱毒性增强会被安克痉以剂量相关的方式拮抗。所呈现的动物实验结果与临床经验相符。
