脊椎按摩疗法对患有阿尔茨海默病和帕金森病的成年人脑电图的影响：一项初步随机交叉试验。

The Effects of Chiropractic Spinal Adjustment on EEG in Adults with Alzheimer's and Parkinson's Disease: A Pilot Randomised Cross-over Trial.

作者信息

Navid Muhammad Samran, Niazi Imran Khan, Holt Kelly, Nedergaard Rasmus Bach, Amjad Imran, Ghani Usman, Kumari Nitika, Shafique Muhammad, Duehr Jenna, Trager Robert J, Haavik Heidi

机构信息

Centre for Chiropractic Research, New Zealand College of Chiropractic, 1060 Auckland, New Zealand.

Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.

出版信息

J Integr Neurosci. 2024 May 11;23(5):98. doi: 10.31083/j.jin2305098.

DOI:10.31083/j.jin2305098

PMID:38812396

Abstract

OBJECTIVES

In this study, we explored the effects of chiropractic spinal adjustments on resting-state electroencephalography (EEG) recordings and early somatosensory evoked potentials (SEPs) in Alzheimer's and Parkinson's disease.

METHODS

In this randomized cross-over study, 14 adults with Alzheimer's disease (average age 67 ± 6 years, 2 females:12 males) and 14 adults with Parkinson's disease (average age 62 ± 11 years, 1 female:13 males) participated. The participants underwent chiropractic spinal adjustments and a control (sham) intervention in a randomized order, with a minimum of one week between each intervention. EEG was recorded before and after each intervention, both during rest and stimulation of the right median nerve. The power-spectra was calculated for resting-state EEG, and the amplitude of the N30 peak was assessed for the SEPs. The source localization was performed on the power-spectra of resting-state EEG and the N30 SEP peak.

RESULTS

Chiropractic spinal adjustment significantly reduced the N30 peak in individuals with Alzheimer's by 15% ( = 0.027). While other outcomes did not reach significance, resting-state EEG showed an increase in absolute power in all frequency bands after chiropractic spinal adjustments in individuals with Alzheimer's and Parkinson's disease. The findings revealed a notable enhancement in connectivity within the Default Mode Network (DMN) at the alpha, beta, and theta frequency bands among individuals undergoing chiropractic adjustments.

CONCLUSIONS

We found that it is feasible to record EEG/SEP in individuals with Alzheimer's and Parkinson's disease. Additionally, a single session of chiropractic spinal adjustment reduced the somatosensory evoked N30 potential and enhancement in connectivity within the DMN at the alpha, beta, and theta frequency bands in individuals with Alzheimer's disease. Future studies may require a larger sample size to estimate the effects of chiropractic spinal adjustment on brain activity. Given the preliminary nature of our findings, caution is warranted when considering the clinical implications.

CLINICAL TRIAL REGISTRATION

The study was registered by the Australian New Zealand Clinical Trials Registry (registration number ACTRN12618001217291 and 12618001218280).

摘要

目的

在本研究中，我们探讨了脊椎按摩疗法对阿尔茨海默病和帕金森病患者静息态脑电图（EEG）记录及早期体感诱发电位（SEP）的影响。

方法

在这项随机交叉研究中，14名阿尔茨海默病成年人（平均年龄67±6岁，女性2名：男性12名）和14名帕金森病成年人（平均年龄62±11岁，女性1名：男性13名）参与其中。参与者按随机顺序接受脊椎按摩疗法和对照（假）干预，每次干预之间至少间隔一周。在每次干预前后，分别在静息状态和刺激右侧正中神经时记录EEG。计算静息态EEG的功率谱，并评估SEP的N30峰值幅度。对静息态EEG的功率谱和N30 SEP峰值进行源定位。

结果

脊椎按摩疗法使阿尔茨海默病患者的N30峰值显著降低了15%（P = 0.027）。虽然其他结果未达到显著水平，但静息态EEG显示，阿尔茨海默病和帕金森病患者在接受脊椎按摩疗法后，所有频段的绝对功率均有所增加。研究结果显示，接受脊椎按摩疗法的个体在α、β和θ频段的默认模式网络（DMN）内的连通性显著增强。

结论

我们发现，在阿尔茨海默病和帕金森病患者中记录EEG/SEP是可行的。此外，单次脊椎按摩疗法可降低阿尔茨海默病患者的体感诱发电位N30电位，并增强其在α、β和θ频段的DMN内的连通性。未来的研究可能需要更大的样本量来评估脊椎按摩疗法对大脑活动的影响。鉴于我们研究结果的初步性质，在考虑其临床意义时应谨慎。