Chen Xuannan, Chen Xi, Lai Yu
Acupunture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Microbiol. 2024 May 15;15:1374582. doi: 10.3389/fmicb.2024.1374582. eCollection 2024.
Antiretroviral therapy has led to AIDS being a chronic disease. Nevertheless, the presence of constantly emerging drug resistance mutations poses a challenge to clinical treatment. A systematic analysis to summarize the advancements and uncharted territory of drug resistance mutations is urgently needed and may provide new clues for solving this problem.
We gathered 3,694 publications on drug resistance mutations from the Web of Science Core Collection with CiteSpace software and performed an analysis to visualize the results and predict future new directions and emerging trends. Betweenness centrality, count, and burst value were taken as standards.
The number of papers on HIV medication resistance mutations during the last 10 years shows a wave-like trend. In terms of nation, organization, and author, the United States (1449), University of London (193), and Mark A. Wainberg (66) are the most significant contributors. The most frequently cited article is "Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update." Hot topics in this field include "next-generation sequencing," "tenofovir alafenamide," "children," "regimens," "accumulation," "dolutegravir," "rilpivirine," "sex," "pretreatment drug resistance," and "open label." Research on drug resistance in teenagers, novel mutation detection techniques, and drug development is ongoing, and numerous publications have indicated the presence of mutations related to current medications. Therefore, testing must be performed regularly for patients who have used medications for a long period. Additionally, by choosing medications with a longer half-life, patients can take fewer doses of their prescription, increasing patient compliance.
This study involved a bibliometric visualization analysis of the literature on drug resistance mutations, providing insight into the field's evolution and emerging patterns and offering academics a resource to better understand HIV drug resistance mutations and contribute to the field's advancement.
抗逆转录病毒疗法已使艾滋病成为一种慢性病。然而，不断出现的耐药性突变对临床治疗构成了挑战。迫切需要进行系统分析以总结耐药性突变的进展和未知领域，这可能为解决该问题提供新线索。
我们使用CiteSpace软件从Web of Science核心合集中收集了3694篇关于耐药性突变的出版物，并进行分析以可视化结果并预测未来的新方向和新兴趋势。以中介中心性、计数和突发值作为标准。
过去10年中关于HIV药物耐药性突变的论文数量呈波浪状趋势。在国家、组织和作者方面，美国（1449篇）、伦敦大学（193篇）和马克·A·温伯格（66篇）是最重要的贡献者。被引用最多的文章是《用于监测传播的HIV-1耐药性的耐药性突变：2009年更新》。该领域的热门话题包括“下一代测序”“替诺福韦艾拉酚胺”“儿童”“治疗方案”“积累”“多替拉韦”“rilpivirine”“性别”“治疗前耐药性”和“开放标签”。对青少年耐药性、新型突变检测技术和药物开发的研究正在进行，大量出版物表明存在与当前药物相关的突变。因此，对于长期使用药物的患者必须定期进行检测。此外，通过选择半衰期较长的药物，患者可以减少服药剂量，提高患者依从性。
本研究对耐药性突变文献进行了文献计量可视化分析，深入了解了该领域的发展和新兴模式，并为学者提供了一个资源，以更好地理解HIV耐药性突变并推动该领域的发展。
