血甲胎蛋白水平显著升高的一种罕见病因：病例报告及文献综述

Zheng Yue, Yao Jianping, Liu Jin, Zhao Feimin

Department of General Medicine, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.

Department of Endocrinology, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.

Front Oncol. 2024 May 15;14:1393074. doi: 10.3389/fonc.2024.1393074. eCollection 2024.

Alpha-fetoprotein (AFP) serves as a crucial diagnostic marker for primary hepatocellular carcinoma (HCC) and germ cell tumors (GCTs), with rare instances of significantly elevated levels in other diseases. In this study, we present a case of an elderly patient who was diagnosed with AFP-producing gastric cancer (AFPGC) following an elevated AFP result during physical examination. In investigating liver cancer at an early stage, the diagnosis was missed because of failure in detecting the lesion, resulting in delayed treatment initiation. AFPGC is a rare aggressive tumor that demands heightened awareness among clinicians to foster early detection, diagnosis, and treatment for improved prognosis.

甲胎蛋白（AFP）是原发性肝细胞癌（HCC）和生殖细胞肿瘤（GCT）的关键诊断标志物，在其他疾病中仅有罕见情况下会显著升高。在本研究中，我们报告了一例老年患者，其在体检时AFP结果升高，随后被诊断为产生AFP的胃癌（AFPGC）。在早期调查肝癌时，由于未能检测到病变而漏诊，导致治疗开始延迟。AFPGC是一种罕见的侵袭性肿瘤，临床医生需要提高认识，以促进早期检测、诊断和治疗，从而改善预后。