Zhou Zhongming, Han Yanyan
Department of Otolaryngology, Shanghai Punan Hospital of Pudong New District, Shanghai, China.
Front Nutr. 2024 May 14;11:1375545. doi: 10.3389/fnut.2024.1375545. eCollection 2024.
The oxidative balance score (OBS), a composite score of dietary nutrients and lifestyles, reflects an individual's oxidative and antioxidant status. Evidence showed that oxidative stress levels were related to hearing loss. The relationship between OBS and hearing loss remains unclear. This study was to explore the association between OBS and hearing loss in adults.
In this cross-sectional study, data of participants aged 20-69 years who received hearing tests were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2011-2012, 2015-2016). Hearing loss was defined as hearing threshold >25 dB in either ear. The OBS was composed of 16 dietary nutrients and 4 lifestyles. The covariates were screened using the backward stepwise regression analysis. The association of OBS and hearing loss was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Subgroups of age, gender, occupational noise exposure, recreational noise exposure, firearm noise exposure, and veteran status were further evaluated the associations. The importance ranking of OBS components was analyzed by the weighted random forest model.
Of the total 3,557 adults, 338 (9.5%) suffered from hearing loss. High OBS levels were associated with lower odds of hearing loss (OR = 0.58, 95%CI: 0.41-0.82), after adjusting age, gender, race, hypertension, tinnitus, recreational noise exposure, and occupational noise exposure. Similar results were discovered in individuals aged50-59 years old (OR = 0.47, 95%CI: 0.24-0.93), aged 60-69 years old (OR = 0.31, 95%CI: 0.16-0.61), with female (OR = 0.44, 95%CI: 0.20-0.96), without occupational noise exposure (OR = 0.31, 95%CI: 0.16-0.62), recreational noise exposure (OR = 0.48, 95%CI: 0.30-0.76), firearm noise exposure (OR = 0.38, 95%CI: 0.19-0.77), and veteran status (OR = 0.57, 95%CI: 0.39-0.82). In OBS components, vitamin B12, total fat and physical activity were important for hearing loss.
Elevated OBS may be associated with hearing health in adults. Appropriate vitamin B12 supplementation, reduction of total fat intake, and increased physical activity may be beneficial to the prevention of hearing loss.
氧化平衡评分（OBS）是饮食营养和生活方式的综合评分，反映个体的氧化和抗氧化状态。有证据表明氧化应激水平与听力损失有关。OBS与听力损失之间的关系尚不清楚。本研究旨在探讨成人中OBS与听力损失之间的关联。
在这项横断面研究中，从国家健康与营养检查调查（NHANES）数据库（2011 - 2012年、2015 - 2016年）中提取接受听力测试的20 - 69岁参与者的数据。听力损失定义为任一耳听力阈值>25dB。OBS由16种饮食营养素和4种生活方式组成。使用向后逐步回归分析筛选协变量。用优势比（OR）和95%置信区间（CI）评估OBS与听力损失的关联。进一步评估年龄、性别、职业噪声暴露、娱乐噪声暴露、火器噪声暴露和退伍军人身份亚组的关联。通过加权随机森林模型分析OBS成分的重要性排名。
在总共3557名成年人中，338人（9.5%）患有听力损失。在调整年龄、性别、种族、高血压、耳鸣、娱乐噪声暴露和职业噪声暴露后，高OBS水平与较低的听力损失几率相关（OR = 0.58，95%CI：0.41 - 0.82）。在50 - 59岁的个体（OR = 0.47，95%CI：0.24 - 0.93）、60 - 69岁的个体（OR = 0.31，95%CI：0.16 - 0.61）、女性（OR = 0.44，95%CI：0.20 - 0.96）、无职业噪声暴露（OR = 0.31，95%CI：0.16 - 0.62）、娱乐噪声暴露（OR = 0.48，95%CI：0.30 - 0.76）、火器噪声暴露（OR = 0.38，95%CI：0.19 - 0.77）和退伍军人身份（OR = 0.57，95%CI：0.39 - 0.82）的个体中发现了类似结果。在OBS成分中，维生素B12、总脂肪和身体活动对听力损失很重要。
升高的OBS可能与成人的听力健康有关。适当补充维生素B12、减少总脂肪摄入和增加身体活动可能有助于预防听力损失。
