Huri Gazi, Özdemir Erdi, Biçer Ömer Sunkar, Yilgör Huri Pınar, Polat Sait, Sapmaz Tuğçe, Doral Mahmut Nedim
Department of Orthopedics and Traumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.
Department of Orthopedics and Traumatology, Faculty of Medicine, Çukurova University Adana, Turkiye.
Turk J Med Sci. 2022 Oct 10;53(5):1379-1386. doi: 10.55730/1300-0144.5704. eCollection 2023.
BACKGROUND/AIM: We have designed an adjustable bone plate (ABP) which allows bone shortening and lengthening after fixation, which is a property not present in any of the plate systems available today. The aim of the current study was to examine the new ABP's segmental bone transfer capability for the treatment of a segmental bone defect in an animal model.
Five sheep had ABPs attached to 10 of their tibias and bone defects of 15 mm in size were created. The pinion mechanism was moved with a manual screwdriver at a rate of 1mm/day for 15 days starting 3 days postoperatively. The animals were euthanized 3 months postoperatively, and the defect site and the transferred segment were evaluated by radiological and histological examination.
The radiological results revealed successful transfers of 14.6 ± 1.2 mm of bone segment on all tibia defects without any complications. The histological evaluation showed new bone formation in both the extension and the docking sites. No rupture or breakage was observed within the plates.
We have presented the potential of a new generation ABP for use in segmental bone transfer in an animal model as well as for future clinical applications.
背景/目的：我们设计了一种可调节接骨板（ABP），其在固定后能够实现骨缩短和延长，这是目前任何现有接骨板系统都不具备的特性。本研究的目的是在动物模型中检验新型ABP治疗节段性骨缺损的节段性骨转移能力。
对5只绵羊的10根胫骨安装ABP，并制造15毫米大小的骨缺损。术后3天开始，用手动螺丝刀以每天1毫米的速度移动小齿轮机构，持续15天。术后3个月对动物实施安乐死，并通过放射学和组织学检查对缺损部位和转移节段进行评估。
放射学结果显示，所有胫骨缺损均成功转移了14.6±1.2毫米的骨段，且无任何并发症。组织学评估显示，延长部位和对接部位均有新骨形成。接骨板内未观察到破裂或折断情况。
我们展示了新一代ABP在动物模型中用于节段性骨转移以及未来临床应用的潜力。
