Nwafor Divine C, Obiri-Yeboah Derrick, Fazad Faraz, Blanks William, Mut Melike
Department of Neurosurgery, University of Virginia, Charlottesville, VA, United States.
Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States.
Front Neurol. 2024 May 15;15:1387986. doi: 10.3389/fneur.2024.1387986. eCollection 2024.
Ultrasound waves were initially used as a diagnostic tool that provided critical insights into several pathological conditions (e.g., gallstones, ascites, pneumothorax, etc.) at the bedside. Over the past decade, advancements in technology have led to the use of ultrasound waves in treating many neurological conditions, such as essential tremor and Parkinson's disease, with high specificity. The convergence of ultrasound waves at a specific region of interest/target while avoiding surrounding tissue has led to the coined term "focused ultrasound (FUS)." In tumor research, ultrasound technology was initially used as an intraoperative guidance tool for tumor resection. However, in recent years, there has been growing interest in utilizing FUS as a therapeutic tool in the management of brain tumors such as gliomas. This mini-review highlights the current knowledge surrounding using FUS as a treatment modality for gliomas. Furthermore, we discuss the utility of FUS in enhanced drug delivery to the central nervous system (CNS) and highlight promising clinical trials that utilize FUS as a treatment modality for gliomas.
超声波最初被用作一种诊断工具，可在床边对多种病理状况（如胆结石、腹水、气胸等）提供关键见解。在过去十年中，技术进步使得超声波被用于治疗许多神经系统疾病，如特发性震颤和帕金森病，具有很高的特异性。超声波在特定感兴趣区域/靶点汇聚，同时避免周围组织受到影响，由此产生了“聚焦超声（FUS）”这一术语。在肿瘤研究中，超声技术最初被用作肿瘤切除的术中引导工具。然而，近年来，人们越来越有兴趣将聚焦超声用作治疗脑肿瘤（如胶质瘤）的治疗工具。这篇小型综述重点介绍了目前有关将聚焦超声用作胶质瘤治疗方式的知识。此外，我们讨论了聚焦超声在增强向中枢神经系统（CNS）给药方面的效用，并重点介绍了利用聚焦超声作为胶质瘤治疗方式的有前景的临床试验。
