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采用 Franz 皮肤有限剂量模型和质谱法对无水渗透增强剂中孕酮经皮吸收的体外评价。

In vitro evaluation of the percutaneous absorption of progesterone in anhydrous permeation-enhancing base using the Franz skin finite dose model and mass spectrometry.

机构信息

Professional Compounding Centers of America (PCCA), 9901 South Wilcrest Drive, Houston, TX, 77099, USA.

Department of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA.

出版信息

Arch Dermatol Res. 2024 May 30;316(6):291. doi: 10.1007/s00403-024-03040-x.

DOI:10.1007/s00403-024-03040-x
PMID:38814486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11139709/
Abstract

Progesterone is used for hormone replacement therapy through various routes of administration. This study was conducted to (a) evaluate the stability of progesterone in a proprietary anhydrous permeation-enhancing base (APEB) and the efficiency of its skin permeation, and (b) determine the appropriateness of mass spectrometry as a method of analysis for permeated progesterone. Using a proven stability-indicating ultra-performance liquid chromatographic method, the compounded hormone (100 mg progesterone/g APEB gel) was determined to be physically and chemically stable at room temperature for six months. Skin permeation analysis using the Franz skin finite dose model and mass spectrometry imaging showed an optical density of 1699 for the permeated progesterone compounded in APEB and 550 for the permeated progesterone in a water containing VBC, which is a statistically significant different (P = 0.029). The study suggests that APEB can be used as a compounding base for effective skin permeation of progesterone, and mass spectrometry is a reliable method for visualization and quantitative analysis of permeated progesterone.

摘要

孕激素通过多种给药途径用于激素替代疗法。本研究旨在：(a)评估专有无水渗透增强基底 (APEB) 中孕激素的稳定性及其皮肤渗透效率，(b)确定质谱法作为渗透孕激素分析方法的适宜性。使用经过验证的稳定性指示超高效液相色谱法，发现复合激素（100mg 孕激素/g APEB 凝胶）在室温下六个月内物理和化学性质稳定。使用 Franz 皮肤有限剂量模型和质谱成像进行皮肤渗透分析，结果表明在 APEB 中复合的渗透孕激素的光密度为 1699，而在含有 VBC 的水中复合的渗透孕激素的光密度为 550，这具有统计学显著差异（P=0.029）。该研究表明，APEB 可用作孕激素有效皮肤渗透的复合基底，质谱法是可视化和定量分析渗透孕激素的可靠方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/33f5248f8b7c/403_2024_3040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/a4536ac8c65b/403_2024_3040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/f9b84e381078/403_2024_3040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/33f5248f8b7c/403_2024_3040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/a4536ac8c65b/403_2024_3040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/f9b84e381078/403_2024_3040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c923/11139709/33f5248f8b7c/403_2024_3040_Fig3_HTML.jpg

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