National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Transl Vis Sci Technol. 2024 May 1;13(5):26. doi: 10.1167/tvst.13.5.26.
We aimed to determine the causal effects of physical activities with different frequencies, durations, and intensities on the risk of senile cataracts using Mendelian randomization (MR).
A bidirectional two-sample MR approach was used to determine the association between physical activity and senile cataract risk. Our primary analysis used the inverse variance weighted method, and secondary analyses included MR-Egger regression, MR-PRESSO, and Cochran's Q statistic to evaluate heterogeneity and pleiotropy. Causal estimates were presented as odds ratios (ORs) with 95% confidence intervals (95% CIs).
Genetically predicted moderate physical activity ≥ 10 min/wk (OR = 0.765, 95% CI = 0.627-0.936, P = 8.73E-03), vigorous physical activity ≥ 10 min/wk (OR = 0.691, 95% CI = 0.521-0.917, P = 1.04E-02), moderate-to-vigorous physical activity levels (OR = 0.552, 95% CI = 0.369-0.823, P = 3.75E-03), and overall acceleration average (OR = 0.952, 95% CI = 0.926-0.978, P = 3.80E-04) were associated with a decreased risk of senile cataract while walking ≥ 10 min/wk (OR = 0.972, 95% CI = 0.741-1.275, P = 8.36E-01) had no significant correlation. The reverse MR analysis showed no reversal causality from senile cataract to physical activity except for walking ≥ 10 min/wk (OR = 0.951, 95% CI = 0.923-0.979, P = 7.30E-04).
Our findings suggest that moderate to vigorous physical activity with higher frequency and longer duration will causally reduce the risk of senile cataracts, and there is no reverse causal relationship.
These findings underscore the potential of incorporating physical activity into preventive health strategies for senile cataracts.
本研究旨在使用孟德尔随机化（Mendelian randomization，MR）方法来确定不同频率、时长和强度的身体活动对老年性白内障风险的因果关系。
采用双向两样本 MR 方法来确定身体活动与老年性白内障风险之间的关联。我们的主要分析采用了逆方差加权法，次要分析包括 MR-Egger 回归、MR-PRESSO 和 Cochran's Q 统计量来评估异质性和多效性。因果估计值以比值比（odds ratio，OR）及其 95%置信区间（95% confidence interval，95%CI）表示。
遗传预测的中度身体活动≥10 分钟/周（OR=0.765，95%CI=0.627-0.936，P=8.73E-03）、剧烈身体活动≥10 分钟/周（OR=0.691，95%CI=0.521-0.917，P=1.04E-02）、中高强度身体活动水平（OR=0.552，95%CI=0.369-0.823，P=3.75E-03）和整体加速度平均值（OR=0.952，95%CI=0.926-0.978，P=3.80E-04）与老年性白内障风险降低相关，而每周步行≥10 分钟（OR=0.972，95%CI=0.741-1.275，P=8.36E-01）与老年性白内障风险之间无显著相关性。反向 MR 分析显示，除了每周步行≥10 分钟（OR=0.951，95%CI=0.923-0.979，P=7.30E-04）外，老年性白内障无反向因果关系。
我们的研究结果表明，较高频率和较长时长的中高强度身体活动可能会导致老年性白内障风险降低，并且不存在反向因果关系。
邹欣
