Department of Encephalopathy, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150001, PR China.
Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150006, PR China; Department of First Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, PR China.
Eur J Pharmacol. 2024 Aug 5;976:176690. doi: 10.1016/j.ejphar.2024.176690. Epub 2024 May 28.
Parkinson's Disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies. While the traditional focus has been on neuronal and glial cell dysfunction, recent research has shifted towards understanding the role of the immune system, particularly dendritic cells (DCs), in PD pathogenesis. As pivotal antigen-presenting cells, DCs are traditionally recognized for initiating and regulating immune responses. In PD, DCs contribute to disease progression through the presentation of α-synuclein to T cells, leading to an adaptive immune response against neuronal elements. This review explores the emerging role of DCs in PD, highlighting their potential involvement in antigen presentation and T cell immune response modulation. Understanding the multifaceted functions of DCs could reveal novel insights into PD pathogenesis and open new avenues for therapeutic strategies, potentially altering the course of this devastating disease.
帕金森病（PD）是一种使人衰弱的神经退行性疾病，其特征是多巴胺能神经元的进行性丧失和路易体的存在。虽然传统上关注的是神经元和神经胶质细胞功能障碍，但最近的研究已经转向了解免疫系统，特别是树突状细胞（DCs）在 PD 发病机制中的作用。作为关键的抗原呈递细胞，DCs通常因其启动和调节免疫反应而被认识。在 PD 中，DCs 通过将α-突触核蛋白呈递给 T 细胞来促进疾病进展，导致针对神经元成分的适应性免疫反应。这篇综述探讨了 DCs 在 PD 中的新作用，强调了它们在抗原呈递和 T 细胞免疫反应调节中的潜在作用。了解 DCs 的多方面功能可以揭示 PD 发病机制的新见解，并为治疗策略开辟新途径，有可能改变这种毁灭性疾病的进程。
