间质性肺异常：当前的认识

Interstitial Lung Abnormalities: Current Understanding.

作者信息

Wada Noriaki, Hunninghake Gary M, Hatabu Hiroto

机构信息

Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Clin Chest Med. 2024 Jun;45(2):433-444. doi: 10.1016/j.ccm.2024.02.013. Epub 2024 Apr 2.

DOI:10.1016/j.ccm.2024.02.013

PMID:38816098

Abstract

Interstitial lung abnormalities (ILAs) are incidental findings on computed tomography scans, characterized by nondependent abnormalities affecting more than 5% of any lung zone. They are associated with factors such as age, smoking, genetic variants, worsened clinical outcomes, and increased mortality. Risk stratification based on clinical and radiological features of ILAs is crucial in clinical practice, particularly for identifying cases at high risk of progression to pulmonary fibrosis. Traction bronchiectasis/bronchiolectasis index has emerged as a promising imaging biomarker for prognostic risk stratification in ILAs. These findings suggest a spectrum of fibrosing interstitial lung diseases, encompassing from ILAs to pulmonary fibrosis.

摘要

间质性肺异常（ILA）是计算机断层扫描中的偶然发现，其特征是不依赖重力的异常影响任何肺区的5%以上。它们与年龄、吸烟、基因变异、临床结局恶化和死亡率增加等因素相关。基于ILA的临床和放射学特征进行风险分层在临床实践中至关重要，特别是对于识别有进展为肺纤维化高风险的病例。牵引性支气管扩张/细支气管扩张指数已成为ILA预后风险分层的一种有前景的影像学生物标志物。这些发现提示了一系列纤维化间质性肺疾病，涵盖从ILA到肺纤维化。