由伊拉普利与氯吡格雷共同给药时CYP450同工型介导的药物-药物相互作用的计算预测。
Computational drug-drug interaction prediction mediated by CYP450 isoforms of Ilaprazole coadministered with clopidogrel.
作者信息
Ananthathandavan Priyadharshini, Narayanasamy Damodharan
机构信息
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur-603203, Chengalpattu, Tamilnadu, India.
Department of Pharmaceutics, SRM college of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Chengalpattu, Tamilnadu, India.
出版信息
Future Sci OA. 2024 May 20;10(1):FSO966. doi: 10.2144/fsoa-2023-0277. eCollection 2024.
Ilaprazole due to its pharmacokinetic variability does not affect the clopidogrel efficacy during concomitant use. Prediction of DDI for Clopidogrel and PPIs performed using (DDI-Pred) Way2Drug software. The probabilities ΔP, which estimate the potential DDIs resulting from interaction with CYP450 isoenzymes. Positive ΔP-values for CYP2C19 (0.955) indicate that it is involved in the drug interaction of Ilaprazole and Clopidogrel. Pantoprazole and Ilaprazole were found to have a low probability of CYP2C19 inhibition Compared with other PPIs, Pantoprazole and Ilaprazole were found to have a low probability of CYP2C19 inhibition; Since Ilaprazole has pharmacokinetic variability, further and studies are required on the ilaprazole and clopidogrel combination to assess the effect of drug-drug interaction.
由于伊拉普利唑的药代动力学变异性，在同时使用期间它不会影响氯吡格雷的疗效。使用（药物相互作用预测）Way2Drug软件对氯吡格雷和质子泵抑制剂之间的药物相互作用进行预测。概率ΔP用于估计与CYP450同工酶相互作用导致的潜在药物相互作用。CYP2C19的正ΔP值（0.955）表明它参与了伊拉普利唑和氯吡格雷的药物相互作用。与其他质子泵抑制剂相比，泮托拉唑和伊拉普利唑对CYP2C19的抑制概率较低；由于伊拉普利唑具有药代动力学变异性，需要进一步研究伊拉普利唑和氯吡格雷的组合，以评估药物相互作用的影响。
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