Gordon L I, Hrushesky W, Oken M M, Kay N E, Rydell R E
Med Pediatr Oncol. 1979;7(2):111-6. doi: 10.1002/mpo.2950070203.
The development of either histiocytic lymphoma or Hodgkin disease in association with pre-existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.
文献中已将组织细胞淋巴瘤或霍奇金病与先前存在的慢性淋巴细胞白血病相关联的发展描述为终末期事件。我们描述了两名患者，他们在生前被诊断出患有第二种恶性淋巴瘤，并且在将治疗方案改为更积极的联合用药后获得了客观的临床缓解。我们得出结论，慢性淋巴细胞白血病患者如果临床病程突然改变，应进行全面重新评估，特别要寻找第二种淋巴增殖性疾病的发生。如果发现这种情况，应开始更积极的治疗。
