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人单核细胞埃立克体病继发的心肌炎

Myocarditis Secondary to Human Monocytotrophic Ehrlichiosis.

作者信息

Kariyawasam Vidhu, Shah Kairav

机构信息

Infectious Diseases, University of Florida, Gainesville, USA.

Infectious Diseases, Southern Regional Medical Center, Atlanta, USA.

出版信息

Cureus. 2024 Apr 30;16(4):e59369. doi: 10.7759/cureus.59369. eCollection 2024 Apr.

DOI:10.7759/cureus.59369
PMID:38817458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11139006/
Abstract

Ehrlichiosis is a tick-borne illness that has been recognized as a source of human infection with increased incidence in the United States over the last decade. The usual presentation is with acute febrile illness, myalgia, malaise with confusion, and central nervous system abnormalities, along with laboratory data concerning transaminitis and hematological abnormalities. Though many complications have been associated with Ehrlichiosis, very few cardiac complications have been reported. We report a rare presentation of Ehrlichiosis in a 63-year-old female who presented with acute fever, transaminitis, and renal failure followed by the development of myocarditis. As part of the diagnostic work-up, an examination of the peripheral smear revealed intracytoplasmic granules in monocytes, which were later confirmed through serology to have Ehrlichia chaffeensis (E. chaffeensis). Given the high degree of initial clinical suspicion, the patient was started on empiric doxycycline and fully recovered with no disease-associated sequelae.

摘要

埃立克体病是一种由蜱传播的疾病,在过去十年中,在美国已被确认为人类感染的一个来源,其发病率呈上升趋势。常见症状为急性发热性疾病、肌痛、伴有意识模糊的不适以及中枢神经系统异常,同时伴有转氨酶升高和血液学异常的实验室检查数据。虽然埃立克体病与许多并发症有关,但报道的心脏并发症却很少。我们报告了一例63岁女性埃立克体病的罕见病例,该患者表现为急性发热、转氨酶升高和肾衰竭,随后发展为心肌炎。作为诊断检查的一部分,对外周血涂片的检查发现单核细胞内有细胞质颗粒,后来通过血清学证实感染了查菲埃立克体(E. chaffeensis)。鉴于最初高度的临床怀疑,患者开始接受经验性强力霉素治疗,最终完全康复,没有出现与疾病相关的后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee11/11139006/118b4c056e64/cureus-0016-00000059369-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee11/11139006/118b4c056e64/cureus-0016-00000059369-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee11/11139006/118b4c056e64/cureus-0016-00000059369-i01.jpg

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本文引用的文献

1
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis.蜱传新发感染:埃立克体病和无形体病
Clin Lab Med. 2017 Jun;37(2):317-340. doi: 10.1016/j.cll.2017.01.006. Epub 2017 Mar 25.
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Human granulocytic anaplasmosis in the United States from 2008 to 2012: a summary of national surveillance data.2008年至2012年美国的人粒细胞无形体病:国家监测数据总结
Am J Trop Med Hyg. 2015 Jul;93(1):66-72. doi: 10.4269/ajtmh.15-0122. Epub 2015 Apr 13.
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Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007.
2000-2007 年美国嗜吞噬细胞无形体和人埃立克体感染发病率的增加。
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Human granulocytic anaplasmosis affecting the myocardium.人粒细胞无形体病累及心肌。
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Rickettsial, ehrlichial and Bartonella infections of the myocardium and pericardium.
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Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila.立克次氏体目里克次体科和无形体科属的重新分类:将埃立克体属的一些物种与无形体属合并、考德里体属与埃立克体属合并以及埃立克体属与新立克次体属合并,六个新物种组合的描述以及将马埃立克体和“人粒细胞埃立克体病病原体”指定为嗜吞噬细胞埃立克体的主观同义词。
Int J Syst Evol Microbiol. 2001 Nov;51(Pt 6):2145-2165. doi: 10.1099/00207713-51-6-2145.
7
Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis.人粒细胞埃立克体病活动期血液学计数的系列测量
Clin Infect Dis. 2001 Mar 15;32(6):862-70. doi: 10.1086/319350. Epub 2001 Mar 7.
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Human granulocytic ehrlichiosis.人粒细胞埃立克体病
Clin Infect Dis. 2000 Aug;31(2):554-60. doi: 10.1086/313948. Epub 2000 Sep 14.
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Fatal pancarditis associated with human granulocytic Ehrlichiosis in a 44-year-old man.
Clin Infect Dis. 1998 Dec;27(6):1424-7. doi: 10.1086/515014.
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Human ehrlichiosis in the United States, 1985 to 1990.1985年至1990年美国的人埃立克体病
Ann Intern Med. 1994 May 1;120(9):736-43. doi: 10.7326/0003-4819-120-9-199405010-00003.