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用于放射治疗中运动管理质量保证的动态拟人化胸部体模

Dynamic anthropomorphic thorax phantom for quality assurance of motion management in radiotherapy.

作者信息

Abdollahi Sara, Mowlavi Ali Asghar, Yazdi Mohammad Hadi Hadizadeh, Ceberg Sofie, Aznar Marianne Camille, Tabrizi Fatemeh Varshoee, Salek Roham, Guckenberger Matthias, Tanadini-Lang Stephanie

机构信息

Department of Physics, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Department of Radiation Oncology, University Hospital Zurich, 8091 Zurich, Switzerland.

出版信息

Phys Imaging Radiat Oncol. 2024 May 6;30:100587. doi: 10.1016/j.phro.2024.100587. eCollection 2024 Apr.

Abstract

BACKGROUND AND PURPOSE

Motion management techniques are important to spare the healthy tissue adequately. However, they are complex and need dedicated quality assurance. The aim of this study was to create a dynamic phantom designed for quality assurance and to replicate a patient's size, anatomy, and tissue density.

MATERIALS AND METHODS

A computed tomography (CT) scan of a cancer patient was used to create molds for the lungs, heart, ribs, and vertebral column via additive manufacturing. A pump system and software were developed to simulate respiratory dynamics. The extent of respiratory motion was quantified using a 4DCT scan. End-to-end tests were conducted to evaluate two motion management techniques for lung stereotactic body radiotherapy (SBRT).

RESULTS

The chest wall moved between 4 mm and 13 mm anteriorly and 2 mm to 7 mm laterally during the breathing. The diaphragm exhibited superior-inferior movement ranging from 5 mm to 16 mm in the left lung and 10 mm to 36 mm in the right lung. The left lung tumor displaced ± 7 mm superior-inferiorly and anterior-posteriorly. The CT numbers were for lung: -716 ± 108 HU (phantom) and -713 ± 70 HU (patient); bone: 460 ± 20 HU (phantom) and 458 ± 206 HU (patient); soft tissue: 92 ± 9 HU (phantom) and 60 ± 25 HU (patient). The end-to-end testing showed an excellent agreement between the measured and the calculated dose for ion chamber and film dosimetry.

CONCLUSIONS

The phantom is recommended for quality assurance, evaluating the institution's specific planning and motion management strategies either through end-to-end testing or as an external audit phantom.

摘要

背景与目的

运动管理技术对于充分保护健康组织至关重要。然而,这些技术很复杂,需要专门的质量保证。本研究的目的是创建一个用于质量保证的动态体模,并复制患者的体型、解剖结构和组织密度。

材料与方法

利用癌症患者的计算机断层扫描(CT)图像,通过增材制造制作肺、心脏、肋骨和脊柱的模具。开发了一个泵系统和软件来模拟呼吸动力学。使用4DCT扫描对呼吸运动范围进行量化。进行端到端测试以评估两种用于肺部立体定向体部放射治疗(SBRT)的运动管理技术。

结果

呼吸过程中胸壁向前移动4毫米至13毫米,向侧面移动2毫米至7毫米。膈肌表现出上下移动,左肺为5毫米至16毫米,右肺为10毫米至36毫米。左肺肿瘤在上下和前后方向上移位±7毫米。CT值方面,肺:-716±108HU(体模)和-713±70HU(患者);骨:460±20HU(体模)和458±206HU(患者);软组织:92±9HU(体模)和60±25HU(患者)。端到端测试表明,对于电离室和胶片剂量测定,测量剂量与计算剂量之间具有良好的一致性。

结论

推荐使用该体模进行质量保证,通过端到端测试或作为外部审核体模来评估机构的特定计划和运动管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41b9/11137593/3fc0e37a1685/gr1.jpg

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