Javadpour N
Urology. 1985 Feb;25(2):155-60. doi: 10.1016/0090-4295(85)90533-3.
Cis-platinum is one of the most efficacious platinum group metals. This agent is widely used in combination with cancer chemotherapy including urologic, gynecologic, esophageal, and head and neck cancers. The initial experience indicated dose-limiting renal nephrotoxicity. However, recent knowledge through animal and clinical experiments have led to finding ways to prevent the undesirable toxicities of this agent even in high doses. The clinical utilization of cisplatinum in various cancers, including testicular, ovarian, bladder, prostate, esophageal, have been encouraging. The use of high-dose cis-platinum (200 mg/m2) has had important therapeutic impact on patients with poor prognostic testicular cancer when compared with the conventional dosage (100 mg/m2). The current use and future potential of this anticancer metal and its potential analogs are reviewed.
顺铂是最有效的铂族金属之一。该药物广泛用于联合癌症化疗，包括泌尿系统、妇科、食管癌以及头颈癌。最初的经验表明存在剂量限制性肾毒性。然而，近期通过动物和临床试验获得的认识已促使人们找到预防该药物即便在高剂量时出现不良毒性的方法。顺铂在包括睾丸癌、卵巢癌、膀胱癌、前列腺癌、食管癌等各种癌症中的临床应用一直令人鼓舞。与传统剂量（100mg/m²）相比，高剂量顺铂（200mg/m²）对预后不良的睾丸癌患者产生了重要的治疗效果。本文综述了这种抗癌金属及其潜在类似物的当前应用情况和未来潜力。
