Cramer B C, Parfrey P S, Hutchinson T A, Baran D, Melanson D M, Ethier R E, Seely J F
Arch Intern Med. 1985 Jan;145(1):87-9.
In a prospective, controlled study undertaken to assess renal function following infusion of radiologic contrast material, serum creatinine level was determined before scan and for three days after scan in 193 patients undergoing computed tomographic (CT) brain scan with contrast enhancement (contrast medium volume, 60 to 350 mL) and in 233 controls undergoing CT scan without infusion. Renal failure developed in four patients who had infusion of contrast material and in three patients who had no infusion (greater than or equal to 50% increase in serum creatinine level and above normal). In the high-risk group (serum creatinine level greater than or equal to 1.5 mg/dL or diabetes mellitus), renal failure developed in none of the 19 patients infused and in two of 46 in the noninfused group. It was concluded that previous uncontrolled studies may have overestimated the risk of renal failure induced by contrast material.
在一项旨在评估注射放射造影剂后肾功能的前瞻性对照研究中，对193例接受增强计算机断层扫描（CT）脑扫描（造影剂用量为60至350 mL）的患者和233例未注射造影剂的对照者在扫描前及扫描后三天测定血清肌酐水平。接受造影剂注射的患者中有4例发生肾衰竭，未接受注射的患者中有3例发生肾衰竭（血清肌酐水平升高大于或等于50%且高于正常水平）。在高危组（血清肌酐水平大于或等于1.5 mg/dL或患有糖尿病）中，接受注射的19例患者均未发生肾衰竭，未接受注射的46例患者中有2例发生肾衰竭。研究得出结论，以往未进行对照的研究可能高估了造影剂所致肾衰竭的风险。
