Vesoulis Z, Petras R E
Arch Pathol Lab Med. 1985 Jan;109(1):40-2.
A 1.5-mm gastrinoma of the duodenal wall was discovered during dissection of a duodenal ulcer in a patient in whom the Zollinger-Ellison (ZE) syndrome was later suspected due to gross autopsy findings. Multiple duodenal ulcers and gastric rugal hypertrophy were noted, and hyperplasia of the parietal cells associated with a duodenal gastrinoma was confirmed by immunohistochemical studies. In many cases of ZE syndrome, a primary neoplasm cannot be localized by angiography, computed tomography, ultrasound, or palpation at exploratory laparotomy. If a neoplasm cannot be identified, many cases will be attributed to islet cell hyperplasia, or antropyloric gastrin cell (G cell) hyperplasia. This case confirms that the primary neoplasm may be grossly undetectable and still produce the clinicomorphologic manifestations of this syndrome.
在一名十二指肠溃疡患者的十二指肠溃疡切除术中，发现了一个位于十二指肠壁的1.5毫米胃泌素瘤。该患者后来因大体尸检结果而怀疑患有佐林格-埃利森（ZE）综合征。术中发现多处十二指肠溃疡和胃黏膜皱襞肥厚，免疫组化研究证实与十二指肠胃泌素瘤相关的壁细胞增生。在许多ZE综合征病例中，原发性肿瘤无法通过血管造影、计算机断层扫描、超声或探查性剖腹术中的触诊来定位。如果无法识别肿瘤，许多病例将归因于胰岛细胞增生或胃窦胃泌素细胞（G细胞）增生。该病例证实，原发性肿瘤在大体上可能无法检测到，但仍会产生该综合征的临床形态学表现。
