Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Ultrason Sonochem. 2024 Jul;107:106928. doi: 10.1016/j.ultsonch.2024.106928. Epub 2024 May 27.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by infiltration of inflammatory cells, hyperplasia of synovium, and destruction of the joint cartilage. Owing to the low drug delivery efficiency and limited immunosuppression effect, complete cure for RA remains a formidable challenge. Here, we show that live macrophages (Mφs) carrying protoporphyrin-loaded FeO nanoparticles can migrate to the RA tissues and inhibit the inflammation by sonodynamic therapy. The inflammation of RA leads to the release of cytokines, which guides the migration of the Mφs into the RA tissues, realizing precise delivery of therapeutics. The following sonodynamic therapy induced by ultrasound and protoporphyrin destructs the proliferating synovial cells and also infiltrated inflammatory cells, demonstrating significant therapeutic effect for RA. Meanwhile, the cytokines and relapse of RA can be remarkably suppressed because of the efficient damage to the resident inflammatory cells.
类风湿性关节炎（RA）是一种慢性系统性炎症性疾病，其特征是炎症细胞浸润、滑膜增生和关节软骨破坏。由于药物递送效率低和免疫抑制效果有限，RA 的完全治愈仍然是一个巨大的挑战。在这里，我们展示了负载原卟啉的 FeO 纳米粒子的活巨噬细胞（Mφs）可以通过声动力学疗法迁移到 RA 组织并抑制炎症。RA 的炎症导致细胞因子的释放，这些细胞因子指导 Mφs 迁移到 RA 组织中，实现治疗药物的精确递送。随后，超声和原卟啉诱导的声动力学疗法破坏了增生的滑膜细胞和浸润的炎症细胞，对 RA 具有显著的治疗效果。同时，由于对常驻炎症细胞的有效损伤，细胞因子和 RA 的复发可以得到显著抑制。
