State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Zhejiang Provincial Key Laboratory of Fruit and Vegetables Postharvest and Processing Technology Research, Ministry of Agriculture and Rural Affairs Key Laboratory of Post-Harvest Handling of Fruits, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Zhejiang Provincial Key Laboratory of Fruit and Vegetables Postharvest and Processing Technology Research, Ministry of Agriculture and Rural Affairs Key Laboratory of Post-Harvest Handling of Fruits, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; School of Agriculture and Food, The University of Melbourne, Parkville, Vic 3010, Australia.
Int J Biol Macromol. 2024 Jul;273(Pt 1):132746. doi: 10.1016/j.ijbiomac.2024.132746. Epub 2024 May 29.
The aim of this work was to evaluate the potentials of porous starch (PS) and its octenyl succinic anhydride modified product (OSAPS) as efficient carriers for loading naringin (NA), focusing on encapsulation efficiency (EE, the percentage of adsorbed naringin relative to its initial amount), drug loading (DL, the percentage of naringin in the complex), structural alterations, solubilization and in vitro release of NA using unmodified starch (UMS) and NA as controls. Both the pore diameter and S value of PS decreased after esterification with OSA, and a thinner strip-shaped NA (∼145 nm) was observed in the OSAPS-NA complex and (∼150 nm) in the PS-NA complex. OSAPS exhibited reduced short-range ordered structure, as indicated by a lower R1047/1022 (0.73) compared to PS (0.77). Meanwhile, lowest crystallinity (12.81 %) of NA was found in OSAPS-NA. OSAPS-NA exhibited higher EE and DL for NA than PS-NA and a significant increase in NA saturated solubility in deionized water (by 11.63-fold) and simulated digestive fluids (by 24.95-fold) compared to raw NA. OSAPS contained higher proportions of slowly digestible starch and exhibited a lower digestion rate compared to PS, resulting in a longer time for NA release from its complex during the digestion.
本工作旨在评估多孔淀粉（PS）及其辛烯基琥珀酸酐改性产物（OSAPS）作为负载柚皮苷（NA）的有效载体的潜力，重点关注包封效率（EE，吸附的 NA 相对于其初始量的百分比）、载药量（DL，复合物中 NA 的百分比）、结构变化、NA 的增溶和体外释放，使用未改性淀粉（UMS）和 NA 作为对照。OSA 酯化后 PS 的孔径和 S 值均降低，在 OSAPS-NA 复合物中观察到较薄的条带状 NA（∼145nm），在 PS-NA 复合物中观察到较薄的条带状 NA（∼150nm）。OSAPS 表现出较低的短程有序结构，这表明与 PS（0.77）相比，R1047/1022（0.73）降低。同时，在 OSAPS-NA 中发现 NA 的结晶度最低（12.81%）。OSAPS-NA 对 NA 的 EE 和 DL 均高于 PS-NA，并且在去离子水（增加 11.63 倍）和模拟消化液（增加 24.95 倍）中的 NA 饱和溶解度显著增加，与原始 NA 相比。OSAPS 含有更高比例的缓慢消化淀粉，并且消化速度低于 PS，导致在消化过程中 NA 从其复合物中释放的时间更长。
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