自身免疫性血小板减少症中的血小板相关免疫球蛋白（PAIgG和PAIgM）

Platelet associated immunoglobulins (PAIgG and PAIgM) in autoimmune thrombocytopenia.

作者信息

Hegde U M, Ball S, Zuiable A, Roter B L

出版信息

Br J Haematol. 1985 Feb;59(2):221-6. doi: 10.1111/j.1365-2141.1985.tb02987.x.

DOI:10.1111/j.1365-2141.1985.tb02987.x

Abstract

An enzyme linked assay system was used to quantitate platelet associated IgM (PAIgM) in addition to platelet associated IgG (PAIgG) in normal subjects and in 145 patients with autoimmune thrombocytopenia (AITP). The mean PAIgM level in normals was 1.17 ng/10(6) platelets with a range of 0.01-2.45 ng (mean +/- 2 SD). The corresponding PAIgG values as follows: mean 6.0 ng, range 2.0-10 ng/10(6) platelets. Elevated PAIgG was seen in 67.6% and abnormally raised PAIgM in 79.3% of patients. Both values were raised together in 57.2% and either elevated PAIgG or PAIgM in 89.7%. All patients with PAIgG values greater than 4 times upper limit of normality were found to have abnormal PAIgM. The relevance of elevated PAIgM, the possible interaction between PAIgG and PAIgM and the implication of our results in patients with autoimmune thrombocytopenia are discussed.

摘要

采用酶联检测系统对正常人和145例自身免疫性血小板减少症（AITP）患者的血小板相关IgG（PAIgG）及血小板相关IgM（PAIgM）进行定量检测。正常人群PAIgM的平均水平为1.17 ng/10⁶血小板，范围为0.01 - 2.45 ng（均值±2标准差）。相应的PAIgG值如下：均值6.0 ng，范围2.0 - 10 ng/10⁶血小板。67.6%的患者PAIgG升高，79.3%的患者PAIgM异常升高。57.2%的患者两者均升高，89.7%的患者PAIgG或PAIgM升高。所有PAIgG值大于正常上限4倍的患者均发现PAIgM异常。讨论了PAIgM升高的相关性、PAIgG与PAIgM之间可能的相互作用以及我们的结果对自身免疫性血小板减少症患者的意义。