Morahan P S, Connor J R, Leary K R
Br Med Bull. 1985 Jan;41(1):15-21. doi: 10.1093/oxfordjournals.bmb.a072017.
Mononuclear phagocytes, including circulating monocytes and tissue macrophages, play a central role in resistance to viruses. This resitance can be expressed both non-specifically, and specifically in indiction, regulation and amplification of humoral and cell mediated immune responses to viruses. These lead to the extrinsic effect of macrophages on other virus-infected cells or free virus, and the intrinsic effect on viruses within macrophages. While these interactions usually appear to be protective, immunopathologic consequences as well as macrophage dysfunctions have also been noted. The outcome of any given interaction (viral elimination, peristance, latency or transformation) varies markedly with the type of macrophage. The molecular mechanisms involved in these very diverse macrophage-virus interactions are currently under study.
单核吞噬细胞，包括循环单核细胞和组织巨噬细胞，在抵抗病毒方面发挥着核心作用。这种抵抗既可以非特异性地表现出来，也可以在对病毒的体液免疫和细胞介导免疫反应的诱导、调节和放大中特异性地表现出来。这些导致巨噬细胞对其他病毒感染细胞或游离病毒的外在作用，以及对巨噬细胞内病毒的内在作用。虽然这些相互作用通常似乎具有保护作用，但也注意到了免疫病理后果以及巨噬细胞功能障碍。任何特定相互作用（病毒清除、持续存在、潜伏或转化）的结果因巨噬细胞类型的不同而有显著差异。目前正在研究这些非常多样的巨噬细胞 - 病毒相互作用所涉及的分子机制。
