Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Arch Dermatol Res. 2024 Jun 1;316(6):324. doi: 10.1007/s00403-024-03047-4.
Alopecia areata (AA), depression, anxiety, and decreased quality of life are highly associated in the literature. It has been noted that there is an increased risk of substance use in those with AA to help cope with the psychological burdens and perceived stigmatization. This study aims to explore the relationship between substance use disorder (SUD) and scarring/non-scarring alopecia using the All of Us database. Of the 9,385 patients with alopecia, 8.4% had SUD of any kind. Multivariable regression revealed that alopecia is a potential protective factor against SUD when controlling for other covariates of significance, with a decreased odds of 0.73. Substance use disorder prevalence was not different between scarring and non-scarring alopecia. This may be the result of patients fearing exacerbation of hair loss, or due to increased mental health and community support in patients with alopecia. Dermatologists and primary care providers should continue to promote psychotherapy and community support to patients whose diagnosis of alopecia has a negative psychosocial impact.
斑秃（AA）、抑郁、焦虑和生活质量下降在文献中高度相关。有研究表明，AA 患者使用物质来帮助应对心理负担和感知到的污名化的风险增加。本研究旨在使用 All of Us 数据库探讨物质使用障碍（SUD）与瘢痕/非瘢痕性脱发之间的关系。在 9385 名脱发患者中，有 8.4%患有任何类型的 SUD。多变量回归显示，在控制其他重要协变量的情况下，脱发是 SUD 的潜在保护因素，其患病几率降低了 0.73。瘢痕性和非瘢痕性脱发之间的物质使用障碍患病率没有差异。这可能是由于患者担心脱发加重，或者由于脱发患者的心理健康和社区支持增加。皮肤科医生和初级保健提供者应继续向因脱发诊断而产生负面影响的患者提供心理治疗和社区支持。
