Gundersen T, Kjekshus J
Clin Cardiol. 1985 Feb;8(2):87-92. doi: 10.1002/clc.4960080205.
The importance of a history of angina pectoris on long-term timolol treatment after myocardial infarction was studied with respect to mortality and reinfarction. The analyses were performed retrospectively using cohorts from the Norwegian timolol multicenter study. In patients without angina pectoris prior to the infarction, timolol treatment reduced mortality by 61% and the occurrence of first nonfatal reinfarction by 16.9% as compared with placebo. Patients with preinfarction angina had a reduction in mortality of 21.8% and in first nonfatal reinfarction of 48.6%. The frequency of angina pectoris increased from 38% in both treatment groups before the infarction to 59% in the placebo group and 52% in the timolol group the first 6 months after the infarction. In patients without postinfarction angina pectoris, timolol treatment reduced mortality by 30.7% and the number of first nonfatal reinfarctions by 22.7%. The reductions in mortality and reinfarction in patients with postinfarction angina were 43.8% and 38.5%, respectively. Thus, the decision for timolol treatment after myocardial infarction should not be dependent on pre- and postinfarction angina.
就死亡率和再梗死而言，研究了心绞痛病史对心肌梗死后长期使用噻吗洛尔治疗的重要性。分析是使用挪威噻吗洛尔多中心研究的队列进行回顾性的。在梗死前无心绞痛的患者中，与安慰剂相比，噻吗洛尔治疗使死亡率降低了61%，首次非致命性再梗死的发生率降低了16.9%。梗死前有心绞痛的患者死亡率降低了21.8%，首次非致命性再梗死降低了48.6%。心绞痛的发生率从梗死前两个治疗组的38%增加到梗死后头6个月安慰剂组的59%和噻吗洛尔组的52%。在梗死后无心绞痛的患者中，噻吗洛尔治疗使死亡率降低了30.7%，首次非致命性再梗死的数量降低了22.7%。梗死后有心绞痛的患者死亡率和再梗死的降低分别为43.8%和38.5%。因此，心肌梗死后噻吗洛尔治疗的决策不应取决于梗死前后是否有心绞痛。
