Brun Paloma, Groisman Boris, Bidondo María Paz, Barbero Pablo, Trotta Marianela, Liascovich Rosa
Red Nacional de Anomalías Congénitas (RENAC), Instituto Nacional de Epidemiología, ANLIS Malbrán, Buenos Aires, Argentina.
Centro de Medicina Traslacional, Hospital de Alta Complejidad El Cruce, Florencio Varela, Provincia de Buenos Aires, Argentina.
J Community Genet. 2024 Aug;15(4):413-422. doi: 10.1007/s12687-024-00714-x. Epub 2024 Jun 1.
Congenital anomalies (CA) encompass all morphological or functional alterations originating prenatally and present at birth. The prenatal diagnosis of these anomalies can significantly impact the overall health of the pregnant individual and may influence her decision regarding the continuation of the pregnancy. In contexts where safe pregnancy termination is not guaranteed by the state, it can lead to unsafe procedures with severe consequences. In our research, we analyzed epidemiological information on CA to develop potential indicators of inequity in access to safe abortion prior to the legalization of legal termination of pregnancy in Argentina. We included cases from 13 public hospitals and 9 non-public subsector hospitals, from the period 2013-2020. Two groups of specific CA were selected: 1) CA capable of being prenatally diagnosed, and 2) CA related to vascular disruptive events. 10/18 of the selected CA capable of being prenatally diagnosed had a significantly higher prevalence in public hospitals (anencephaly, encephalocele, spina bifida, microcephaly, hydrocephalus, holoprosencephaly, hydranencephaly, diaphragmatic hernia, gastroschisis, bilateral renal agenesis). Non public hospitals had higher prenatal detection. Birth prevalence of CA related with vascular disruptive events (limb reduction, Moebius syndrome, amniotic band sequence) were significantly higher in public hospitals. These results suggest disparities in access to prenatal diagnosis and safe abortion based on socioeconomic status. There was a significant gap in access to prenatal diagnosis for CA and possibly to safe elective abortion depending on the type of institution (public vs. non-public).
先天性异常(CA)包括所有产前发生并在出生时就存在的形态或功能改变。这些异常的产前诊断会对孕妇的整体健康产生重大影响,并可能影响她关于继续妊娠的决定。在国家不保障安全终止妊娠的情况下,这可能导致不安全的手术并产生严重后果。在我们的研究中,我们分析了关于先天性异常的流行病学信息,以制定阿根廷合法终止妊娠合法化之前获得安全堕胎机会不平等的潜在指标。我们纳入了2013年至2020年期间13家公立医院和9家非公立部门医院的病例。选择了两组特定的先天性异常:1)能够进行产前诊断的先天性异常,以及2)与血管破坏事件相关的先天性异常。在能够进行产前诊断的所选先天性异常中,10/18在公立医院的患病率显著更高(无脑儿、脑膨出、脊柱裂、小头畸形、脑积水、前脑无裂畸形、积水性无脑畸形、膈疝、腹裂、双侧肾缺如)。非公立医院的产前检测率更高。与血管破坏事件相关的先天性异常(肢体短小、莫比乌斯综合征、羊膜带序列)的出生患病率在公立医院显著更高。这些结果表明,基于社会经济地位在获得产前诊断和安全堕胎方面存在差异。根据机构类型(公立与非公立),在获得先天性异常的产前诊断以及可能的安全选择性堕胎方面存在显著差距。