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胰岛中胰高血糖素原的鉴定与加工

Identification and processing of proglucagon in pancreatic islets.

作者信息

Patzelt C, Tager H S, Carroll R J, Steiner D F

出版信息

Nature. 1979 Nov 15;282(5736):260-6. doi: 10.1038/282260a0.

DOI:10.1038/282260a0
PMID:388230
Abstract

Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,000-MW protein lacking this hormonal sequence.

摘要

对大鼠胰岛新合成蛋白质进行免疫沉淀和胰蛋白酶肽分析，已确定一种分子量为18,000的蛋白质为胰高血糖素原。这种前体的转化在动力学上与胰岛素原的转化相似，并导致形成胰腺胰高血糖素和一种缺乏该激素序列的分子量为10,000的蛋白质。

相似文献

1
Identification and processing of proglucagon in pancreatic islets.胰岛中胰高血糖素原的鉴定与加工
Nature. 1979 Nov 15;282(5736):260-6. doi: 10.1038/282260a0.
2
Identification of prosomatostatin in pancreatic islets.
Proc Natl Acad Sci U S A. 1980 May;77(5):2410-4. doi: 10.1073/pnas.77.5.2410.
3
Relationship of glicentin to proglucagon and glucagon in the porcine pancreas.猪胰腺中甘丙肽与胰高血糖素原及胰高血糖素的关系。
Nature. 1981 Feb 5;289(5797):514-6. doi: 10.1038/289514a0.
4
Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.胰脏α细胞中胰高血糖素原的转化：主要终产物是胰高血糖素和一种单一肽段，即主要的胰高血糖素原片段，其包含两个胰高血糖素样序列。
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5007-11. doi: 10.1073/pnas.81.16.5007.
5
Cell-free synthesis and processing of multiple precursors to glucagon.胰高血糖素多种前体的无细胞合成与加工
Nature. 1981 Feb 5;289(5797):511-4. doi: 10.1038/289511a0.
6
Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets.葡萄糖调节大鼠胰岛中胰岛素原和生长抑素原的水平，但不调节胰高血糖素原信使核糖核酸的水平。
Endocrinology. 2000 Jan;141(1):174-80. doi: 10.1210/endo.141.1.7230.
7
The major proglucagon fragment: an abundant islet protein and secretory product.主要胰高血糖素原片段：一种丰富的胰岛蛋白和分泌产物。
FEBS Lett. 1981 Jun 29;129(1):127-30. doi: 10.1016/0014-5793(81)80772-7.
8
Studies on proinsulin and problucagon biosynthesis and conversion at the subcellular level. II. Distribution of radioactive peptide hormones and hormone precursors in subcellular fractions after pulse and pulse-chase incubation of islet tissue.亚细胞水平上胰岛素原和胰高血糖素生物合成及转化的研究。II. 胰岛组织脉冲和脉冲追踪孵育后亚细胞组分中放射性肽类激素和激素前体的分布。
J Cell Biol. 1977 Aug;74(2):589-604. doi: 10.1083/jcb.74.2.589.
9
Pancreatic proglucagon processing: isolation and structures of glucagon and glucagon-like peptide from gene I.胰高血糖素原的加工：来自基因I的胰高血糖素和胰高血糖素样肽的分离与结构
Endocrinology. 1988 Dec;123(6):2639-45. doi: 10.1210/endo-123-6-2639.
10
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.前胰高血糖素在α TC1-6细胞中被激素原转化酶PC2加工成胰高血糖素。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3242-6. doi: 10.1073/pnas.91.8.3242.

引用本文的文献

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Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity.胰高血糖素及其他胰高血糖素原衍生肽在肥胖发病机制中的作用
Front Nutr. 2022 Aug 4;9:964406. doi: 10.3389/fnut.2022.964406. eCollection 2022.
2
Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity.平衡之道：GLP-1/胰高血糖素共激动剂作为肥胖治疗策略。
Front Endocrinol (Lausanne). 2021 Sep 8;12:735019. doi: 10.3389/fendo.2021.735019. eCollection 2021.
3
Glucagon-like peptide 1 (GLP-1).胰高血糖素样肽 1（GLP-1）。
Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30.
4
From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy.从肠促胰岛素概念和GLP-1的发现到当今的糖尿病治疗
Front Endocrinol (Lausanne). 2019 Apr 26;10:260. doi: 10.3389/fendo.2019.00260. eCollection 2019.
5
Intra-islet glucagon-like peptide 1.胰岛内胰高血糖素样肽1
J Diabetes Complications. 2016 Nov-Dec;30(8):1651-1658. doi: 10.1016/j.jdiacomp.2016.05.016. Epub 2016 May 20.
6
Progressive change of intra-islet GLP-1 production during diabetes development.糖尿病发展过程中胰岛内胰高血糖素样肽-1分泌的渐进性变化。
Diabetes Metab Res Rev. 2014 Nov;30(8):661-8. doi: 10.1002/dmrr.2534.
7
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.由胰高血糖素样肽-1受体（GLP-1R）激活介导的生理和受体多效性效应的分子机制。
Br J Pharmacol. 2014 Mar;171(5):1114-28. doi: 10.1111/bph.12313.
8
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.前胰高血糖素在α TC1-6细胞中被激素原转化酶PC2加工成胰高血糖素。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3242-6. doi: 10.1073/pnas.91.8.3242.
9
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.胰高血糖素原前体 cDNA 包含两个串联排列的与胰高血糖素相关的编码序列。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):345-9. doi: 10.1073/pnas.79.2.345.
10
Identification and localization of glucagon-related peptides in rat brain.大鼠脑中胰高血糖素相关肽的鉴定与定位
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6229-33. doi: 10.1073/pnas.77.10.6229.