胰岛中胰高血糖素原的鉴定与加工
Identification and processing of proglucagon in pancreatic islets.
作者信息
Patzelt C, Tager H S, Carroll R J, Steiner D F
出版信息
Nature. 1979 Nov 15;282(5736):260-6. doi: 10.1038/282260a0.
DOI:10.1038/282260a0
PMID:388230
Abstract
Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,000-MW protein lacking this hormonal sequence.
摘要
对大鼠胰岛新合成蛋白质进行免疫沉淀和胰蛋白酶肽分析，已确定一种分子量为18,000的蛋白质为胰高血糖素原。这种前体的转化在动力学上与胰岛素原的转化相似，并导致形成胰腺胰高血糖素和一种缺乏该激素序列的分子量为10,000的蛋白质。
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