近期刺激响应型聚合物胶束用于功能纳米颗粒靶向递送的进展。

Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles.

机构信息

College of Materials Science and Engineering, Guizhou Minzu University, Guiyang 550025, China.

School of Biomedical Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia; The Biophotonics and Mechano-Bioengineering Lab, The University of Sydney, Sydney, New South Wales 2006, Australia.

出版信息

Adv Colloid Interface Sci. 2024 Aug;330:103206. doi: 10.1016/j.cis.2024.103206. Epub 2024 May 29.

DOI:10.1016/j.cis.2024.103206

PMID:38823215

Abstract

Stimuli-responsive polymeric micelles have emerged as a revolutionary approach for enhancing the in vivo stability, biocompatibility, and targeted delivery of functional nanoparticles (FNPs) in biomedicine. This article comprehensively reviews the preparation methods of these polymer micelles, detailing the innovative strategies employed to introduce stimulus responsiveness and surface modifications essential for precise targeting. We delve into the breakthroughs in utilizing these micelles to selectively deliver various FNPs including magnetic nanoparticles, upconversion nanoparticles, gold nanoparticles, and quantum dots, highlighting their transformative impact in the biomedical realm. Concluding, we present an insight into the current research landscape, addressing the challenges at hand, and envisioning the future trajectory in this burgeoning domain. Join us as we navigate the exciting confluence of polymer science and nanotechnology in reshaping biomedical solutions.

摘要

刺激响应型聚合物胶束作为一种革命性的方法，已广泛应用于提高功能纳米颗粒（FNPs）在生物医学中的体内稳定性、生物相容性和靶向递送。本文全面综述了这些聚合物胶束的制备方法，详细介绍了引入刺激响应性和表面修饰所采用的创新策略，这些修饰对于精确靶向至关重要。我们深入探讨了利用这些胶束选择性递送各种 FNPs 的突破，包括磁性纳米颗粒、上转换纳米颗粒、金纳米颗粒和量子点，强调了它们在生物医学领域的变革性影响。最后，我们对当前的研究现状进行了深入分析，探讨了所面临的挑战，并展望了这一新兴领域的未来发展方向。让我们一起探索聚合物科学和纳米技术的交汇点，共同重塑生物医学解决方案。