Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Lucknow, Uttar Pradesh 226002, India.
Curr Pharm Des. 2022;28(11):910-921. doi: 10.2174/1381612827666211208150210.
Recent studies have been reported emerging polymeric nanoparticles as a promising particulate carrier system for controlled and targeted drug delivery. Stimuli-responsive nanocarriers have shown characteristics, such as high drug uptake at specific sites or targeted cells with an advantage of no drug leakage. These stimuli-responsive polymeric systems are used to functionalize nanocarriers, such as dendrimers, metallic nanoparticles, polymeric nanoparticles, liposomal nanoparticles, and quantum dots.
The study reviews the potential of smart stimuli-responsive carriers for therapeutic application and their behavior in external or internal stimuli, like pH, temperature, redox, light, and magnetic field. These stimuli- responsive drug delivery systems exhibit different drug release patterns in in vitro and in vivo studies. Stimuli- responsive nanocarriers are useful for both hydrophilic and hydrophobic drugs and release them on applied stimulus. This review highlights the recent development in the physical properties of polymeric materials and their application in stimuli-responsive specific drug delivery.
The stimuli (smart, intelligent, programmable) drug delivery systems provide site-specific drug delivery with potential therapy for cancer, neurodegenerative, and lifestyle disorders. The stimuli-responsive- based nanocarriers are developing at a fast pace, and there is a huge demand for biocompatible and biodegradable responsive polymers for effective and safe delivery.
最近的研究报告表明，新兴的聚合纳米粒子作为一种有前途的微粒载体系统，可用于控制和靶向药物输送。刺激响应型纳米载体具有在特定部位或靶向细胞摄取高药物的特点，且药物不会泄漏。这些刺激响应型聚合系统用于对纳米载体进行功能化，如树状大分子、金属纳米粒子、聚合纳米粒子、脂质体纳米粒子和量子点。
本研究综述了智能刺激响应载体在治疗中的应用潜力及其在外部或内部刺激（如 pH 值、温度、氧化还原、光和磁场）下的行为。这些刺激响应型药物输送系统在体外和体内研究中表现出不同的药物释放模式。刺激响应型纳米载体对亲水性和疏水性药物都有效，并在施加刺激时释放药物。本文综述了近年来聚合材料的物理性质及其在刺激响应型特定药物输送中的应用进展。
刺激（智能、智能、可编程）药物输送系统可提供针对特定部位的药物输送，为癌症、神经退行性疾病和生活方式紊乱提供潜在的治疗方法。基于刺激响应的纳米载体发展迅速，对用于有效和安全输送的生物相容性和可生物降解响应性聚合物有巨大的需求。
