Wei Meiqi, Meng Deyu, He Shichun, Guo Hongzhi, Yang Guang, Wang Ziheng
Chinese Center of Exercise Epidemiology, Northeast Normal University, Renmin Street, Changchun, 130024, Jilin, China.
Graduate School of Human Sciences, Waseda University, Tokorozawa, 169-8050, Saitama, Japan.
Alcohol. 2024 Nov;120:15-24. doi: 10.1016/j.alcohol.2024.05.002. Epub 2024 May 30.
Alcohol dependence, influenced by physical activity (PA) and sedentary behavior, lacks clear causal clarity. This study aims to clarify causal relationships by estimating these effects using bidirectional two-sample Mendelian randomization (MR).
A bidirectional multivariable two-sample MR framework was employed to assess the causal effects of PA and sedentary behavior on alcohol dependence. Summarized genetic association data were analyzed for four PA-related activity patterns-moderate to vigorous physical activity (MVPA), vigorous physical activity (VPA), accelerometer-based physical activity with average acceleration (AccAve), and accelerometer-based physical activity with accelerations greater than 425 milli-gravities (Acc425)-and three sedentary behavior patterns-sedentary, TV watching, and computer use. The study was expanded to include the examination of the relationship between sedentary behavior or PA and general drinking behavior, quantified as drinks per week (DPW). We obtained summarized data on genetic associations with four PA related activity patterns (MVPA, VPA, AccAve and Acc425) and three sedentary behavior related behavior patterns (sedentary, TV watching and computer use).
MR analysis found AccAve inversely associated with alcohol dependence risk (OR: 0.87; 95% CI: 0.80-0.95; p < 0.001), MVPA positively associated (OR: 2.86; 95%CI: 1.45-5.66; p = 0.002). For sedentary behavior and alcohol dependence, only TV watching was positively associated with the risk of alcohol dependence (OR: 1.43; 95%CI: 1.09-1.88; p = 0.009). No causal links found for other physical or sedentary activities. Reverse analysis and sensitivity tests showed consistent findings without pleiotropy or heterogeneity. Multivariate MR analyses indicated that while MVPA, AccAve and TV watching are independently associated with alcohol dependence, DPW did not show a significant causal relationship.
Our results suggest that AccAve is considered a protective factor against alcohol dependence, while MVPA and TV watching are considered risk factors for alcohol dependence. Conversely, alcohol dependence serves as a protective factor against TV watching. Only TV watching and alcohol dependence might mutually have a significant causal effect on each other.
酒精依赖受身体活动（PA）和久坐行为影响，因果关系尚不明确。本研究旨在通过双向双样本孟德尔随机化（MR）估计这些影响来阐明因果关系。
采用双向多变量双样本MR框架评估PA和久坐行为对酒精依赖的因果效应。分析了四种与PA相关的活动模式——中度至剧烈身体活动（MVPA）、剧烈身体活动（VPA）、基于加速度计的平均加速度身体活动（AccAve）和基于加速度计的大于425毫重力加速度身体活动（Acc425）——以及三种久坐行为模式——久坐、看电视和使用电脑——的汇总遗传关联数据。该研究扩展到包括检查久坐行为或PA与一般饮酒行为之间的关系，一般饮酒行为以每周饮酒量（DPW）量化。我们获得了与四种PA相关活动模式（MVPA、VPA、AccAve和Acc425）以及三种久坐行为相关行为模式（久坐、看电视和使用电脑）的遗传关联汇总数据。
MR分析发现AccAve与酒精依赖风险呈负相关（OR：0.87；95%CI：0.80 - 0.95；p < 0.001），MVPA呈正相关（OR：2.86；95%CI：1.45 - 5.66；p = 0.002）。对于久坐行为和酒精依赖，仅看电视与酒精依赖风险呈正相关（OR：1.43；95%CI：1.09 - 1.88；p = 0.009）。未发现其他身体活动或久坐活动存在因果联系。反向分析和敏感性测试显示结果一致，无多效性或异质性。多变量MR分析表明，虽然MVPA、AccAve和看电视与酒精依赖独立相关，但DPW未显示出显著的因果关系。
我们的结果表明，AccAve被认为是预防酒精依赖的保护因素，而MVPA和看电视被认为是酒精依赖的风险因素。相反，酒精依赖是预防看电视的保护因素。只有看电视和酒精依赖可能相互存在显著的因果效应。
