Department of Biotechnology, Molecular Informatics Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal 721102, India.
Gene. 2024 Oct 30;926:148627. doi: 10.1016/j.gene.2024.148627. Epub 2024 May 31.
Random mutations increase genetic variety and natural selection enhances adaption over generations. Codon usage biases (CUB) provide clues about the genome adaptation mechanisms of native species and extremophile species. Significant numbers of gene (CDS) of nine classes of endangered, native species, including extremophiles and mesophiles were utilised to compute CUB. Codon usage patterns differ among the lineages of endangered and extremophiles with native species. Polymorphic usage of nucleotides with codon burial suggests parallelism of native species within relatively confined taxonomic groups. Utilizing the deviation pattern of CUB of endangered and native species, I present a calculation parameter to estimate the extinction risk of endangered species. Species diversity and extinction risk are both positively associated with the propensity of random mutation in CDS (Coding DNA sequence). Codon bias tenet profoundly selected and it governs to adaptive evolution of native species.
随机突变增加了遗传多样性，自然选择在几代人的时间里提高了适应性。密码子使用偏好（CUB）为本土物种和极端微生物物种的基因组适应机制提供了线索。利用濒危的、包括极端微生物在内的 9 个类别的本土物种的大量基因（CDS）来计算 CUB。濒危和极端微生物的谱系之间的密码子使用模式存在差异。具有密码子埋藏的核苷酸多态性使用表明，相对有限的分类群内的本土物种具有并行性。利用濒危和本土物种的 CUB 偏差模式，我提出了一个计算参数来估计濒危物种的灭绝风险。物种多样性和灭绝风险都与 CDS（编码 DNA 序列）中随机突变的倾向呈正相关。密码子偏倚原则深刻地选择了它，并控制了本土物种的适应性进化。
