Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Cell Signal. 2024 Aug;120:111240. doi: 10.1016/j.cellsig.2024.111240. Epub 2024 May 31.
Ovarian cancer is one of the most common malignant tumors in women, and treatment options are limited. Despite efforts to adjust cancer treatment models and develop new methods, including tumor microenvironment (TME) therapy, more theoretical support is needed. Increasing attention is being given to antiangiogenic measures for TME treatment. Another important concept in ovarian cancer TME is angiogenesis, where tumor cells obtain nutrients and oxygen from surrounding tissues through blood vessels to support further expansion and metastasis. Many neovascularization signaling pathways become imbalanced and hyperactive during this process. Inhibiting these abnormal pathways can yield ideal therapeutic effects in patients, even by reversing drug resistance. However, these deep TME signaling pathways often exhibit crosstalk and correlation. Understanding these interactions may be an important strategy for further treating ovarian cancer. This review summarizes the latest progress and therapeutic strategies for these angiogenic signaling pathways in ovarian cancer.
卵巢癌是女性最常见的恶性肿瘤之一，治疗选择有限。尽管努力调整癌症治疗模式并开发新方法，包括肿瘤微环境 (TME) 治疗，但仍需要更多的理论支持。越来越多的人关注 TME 治疗的抗血管生成措施。卵巢癌 TME 的另一个重要概念是血管生成，其中肿瘤细胞通过血管从周围组织中获取营养和氧气，以支持进一步的扩张和转移。在此过程中，许多新血管生成信号通路变得失衡和过度活跃。抑制这些异常通路可以在患者中产生理想的治疗效果，甚至可以逆转耐药性。然而，这些深部 TME 信号通路经常表现出串扰和相关性。了解这些相互作用可能是进一步治疗卵巢癌的重要策略。本文综述了这些血管生成信号通路在卵巢癌中的最新进展和治疗策略。
